Publications de Randy Patrick Carney

Selective Localization of Hierarchically Assembled Particles to Plasma Membranes of Living Cells

Francesco Stellacci, Randy Patrick Carney

Particles that preferentially partition to a specific cellular subunit, such as the nucleus, mitochondria, or the cytoskeleton, are of relevance to a number of applications, including drug delivery, genetic manipulation, or self-assembly. Here, hierarchica ...

WILEY-V C H VERLAG GMBH2019

Structure-Property Relationships of Amphiphilic Nanoparticles That Penetrate or Fuse Lipid Membranes

Francesco Stellacci, Davide Demurtas, Paulo Henrique Jacob Silva, Randy Patrick Carney, Ye Yang, Ahmet Bekdemir, Zekiye Pelin Güven

2018

Superparamagnetic Nanoparticles as High Efficiency Magnetic Resonance Imaging T-2 Contrast Agent

Henrik Moodysson Rønnow, Francesco Stellacci, Kurt Schenk, Lin Yang, Ping Huang, Arash Alahgholipour Omrani, Paulo Henrique Jacob Silva, Randy Patrick Carney, Tamara Michael Carney

Nanoparticle-based magnetic resonance imaging T-2 negative agents are of great interest, and much effort is devoted to increasing cell loading capability while maintaining low cytotoxicity. Herein, two classes of mixed-ligand protected magnetic-responsive, ...

American Chemical Society2017

Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months

Francesco Stellacci, Paulo Henrique Jacob Silva, Valeria Cagno, Randy Patrick Carney

Up to 80% of the cost of vaccination programmes is due to the cold chain problem (that is, keeping vaccines cold). Inexpensive, biocompatible additives to slow down the degradation of virus particles would address the problem. Here we propose and character ...

Nature Publishing Group2016

A silica-based magnetic platform decorated with mixed ligand gold nanoparticles: a recyclable catalyst for esterification reactions

Francesco Stellacci, Randy Patrick Carney, Elif Ertem Bekdemir, Emma-Rose Janecek

A novel and convenient synthetic strategy for the preparation of magnetically responsive silica nanospheres decorated with mixed ligand protected gold nanoparticles is described. Gold nanoparticles are attached to the silica surface via stable amide bond f ...

Royal Society of Chemistry2016

Influence of the glycocalyx and plasma membrane composition on amphiphilic gold nanoparticle association with erythrocytes

Francesco Stellacci, Paulo Henrique Jacob Silva, Ahmet Bekdemir, Randy Patrick Carney, Ye Yang

Erythrocytes are attractive as potential cell-based drug carriers because of their abundance and long life-span in vivo. Existing methods for loading drug cargos into erythrocytes include hypotonic treatments, electroporation, and covalent attachment onto ...

Royal Society of Chemistry2015

Isolation and Characterization of Monodisperse Core Shell Nanoparticle Fractions

Francesco Stellacci, Randy Patrick Carney, Raffaele Mezzenga

Monodispersity is a key property to control the self-assembly of colloidal particles, and is typically reached after fine-tuning of the synthesis conditions. Monodisperse particle fractions can also be separated from polydisperse suspensions via ultracentr ...

American Chemical Society2015

Effects of Surface Compositional and Structural Heterogeneity on Nanoparticle-Protein Interactions: Different Protein Configurations

Francesco Stellacci, Randy Patrick Carney

As nanoparticles (NPs) enter into biological systems, they are immediately exposed to a variety and concentration of proteins. The physicochemical interactions between proteins and NPs are influenced by the surface properties of the NPs. To identify the ef ...

American Chemical Society2014

Enhancing Radiotherapy by Lipid Nanocapsule-Mediated Delivery of Amphiphilic Gold Nanoparticles to Intracellular Membranes

Francesco Stellacci, Randy Patrick Carney, Ye Yang

Amphiphilic gold nanoparticles (amph-NPs), composed of gold cores surrounded by an amphiphilic mixed organic ligand shell, are capable of embedding within and traversing lipid membranes. Here we describe a strategy using crosslink-stabilized lipid nanocaps ...

American Chemical Society2014

A general mechanism for intracellular toxicity of metal-containing nanoparticles

Francesco Stellacci, Randy Patrick Carney

The assessment of the risks exerted by nanoparticles is a key challenge for academic, industrial, and regulatory communities worldwide. Experimental evidence points towards significant toxicity for a range of nanoparticles both in vitro and in vivo. Worldw ...

Royal Society of Chemistry2014