Randy Patrick Carney

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Publications associées (20)

Protein-nanoparticle interactions: the effects of surface compositional and structural heterogeneity are scale dependent

Francesco Stellacci, Randy Patrick Carney

Nanoparticles (NPs) in the biological environment are exposed to a large variety and concentration of proteins. Proteins are known to adsorb in a 'corona' like structure on the surface of NPs. In this study, we focus on the effects of surface compositional ...

Royal Society of Chemistry2013

Colloidal Stability of Self-Assembled Mono layer-Coated Gold Nanoparticles: The Effects of Surface Compositional and Structural Heterogeneity

Francesco Stellacci, Randy Patrick Carney

Surface heterogeneity plays an important role in controlling colloidal phenomena. This study investigated the self-aggregation and bacterial adsorption of self-assembled monolayer coated gold nanoparticles (AuNPs) with different surface compositional and s ...

American Chemical Society2013

Electrical Method to Quantify Nanoparticle Interaction with Lipid Bilayers

Francesco Stellacci, Kislon Voitchovsky, Paulo Henrique Jacob Silva, Randy Patrick Carney, Tamara Michael Carney

Understanding as well as rapidly screening the interaction of nanoparticles with cell membranes is of central importance for biological applications such as drug and gene delivery. Recently, we have shown that "striped" mixed-monolayer-coated gold nanopart ...

American Chemical Society2013

Sensing Single Mixed-Monolayer Protected Gold Nanoparticles by the alpha-Hemolysin Nanopore

Francesco Stellacci, Randy Patrick Carney

Gold nanoparticles are widely used in various applications in fields including chemistry, engineering, biology, medicine, and electronics. These materials can be synthesized and modified with ligands containing different functional groups. Among nanopartic ...

American Chemical Society2013

Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers

Francesco Stellacci, Randy Patrick Carney, Ye Yang

Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free e ...

American Chemical Society2013

Cell-Penetrating Nanoparticles : Characterization and Function

Randy Patrick Carney

For targeted cellular therapy using both synthetic and natural biomaterials, there is a need for better understanding of cell penetration mechanisms. Recently, nanoparticles (NPs) coated with mixed-ligand self-assembled monolayers exhibiting order in their ...

EPFL2013

Dynamic Cellular Uptake of Mixed-Monolayer Protected Nanoparticles

Francesco Stellacci, Randy Patrick Carney, Tamara Michael Carney, Marie Mueller

Nanoparticles (NPs) are gaining increasing attention for potential application in medicine; consequently, studying their interaction with cells is of central importance. We found that both ligand arrangement and composition on gold nanoparticles play a cru ...

American Vacuum Society2012

Synthesis and Characterization of Janus Gold Nanoparticles

Francesco Stellacci, Quy Ong Khac, Randy Patrick Carney, Javier Reguera Gomez

When gold nanoparticles are coated with binary mixtures of dislike ligand molecules, separation in the ligand shell occurs; if the particles are smaller than a threshold size the separation is solely enthalpy driven leading to the spontaneous formation of ...

Wiley2012

Determination of nanoparticle size distribution together with density or molecular weight by 2D analytical ultracentrifugation

Francesco Stellacci, Randy Patrick Carney, Jiwon Kim

Nanoparticles are finding many research and industrial applications, yet their characterization remains a challenge. Their cores are often polydisperse and coated by a stabilizing shell that varies in size and composition. No single technique can character ...

Nature Research2011

Oligonucleotide Delivery by Cell-Penetrating "Striped" Nanoparticles

Francesco Stellacci, Randy Patrick Carney

Gold nanoparticles coated with homogeneous (MUS) or "striped" (MUS-OT) ligand shells can be conjugated with double or single stranded DNA, and particles with either ligand configuration effectively carry DNA into melanoma tumor cells. When endocytosis is i ...

Wiley-VCH Verlag GmbH2011

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