Personne

Ulrike Kettenberger

Publications associées (9)

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Non-setting, injectable biomaterials containing particulate hydroxyapatite can increase primary stability of bone screws in cancellous bone

Dominique Pioletti, Ulrike Kettenberger, Jorge Solana Munoz

BACKGROUND: Fracture fixation in weak bone is still a clinical challenge. Screw augmentation was shown to successfully increase their primary stability. The currently used calcium phosphate or polymeric bone cements, however, present important drawbacks su ...

2018

In vitro and in vivo investigation of bisphosphonate-loaded hydroxyapatite particles for peri-implant bone augmentation

Dominique Pioletti, Ulrike Kettenberger

Locally applied bisphosphonates, such as Zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite particle ...

Wiley-Blackwell2017

Active Agent-Particle Combination Supporting Bone Regeneration

Dominique Pioletti, Ulrike Kettenberger

The invention provides for a bioactive composition comprising solid particles, such as e.g. calcium phosphate particles, loaded with an active agent, preferably an osteoconductive/osteoinductive agent or an anti-resorptive agent like a bisphosphonate. The ...

2017

Composition for bone regeneration

Dominique Pioletti, Ulrike Kettenberger

The composition for bone regeneration, comprises a) a first phase (3) comprising a plurality of cross-linked hydrogel chunks (1) having a mean diameter of less than 1000 μm and incorporating an amount of mineral particles (2); and b) a second phase (4) com ...

2017

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A good fixation of osteosynthesis implants is crucial for a successful bone healing but often difficult to achieve in osteoporotic patients. One possible solution to this issue is the local delivery of bisphosphonates in direct proximity to the implants, A ...

Elsevier2015

The role of energy dissipation of polymeric scaffolds in the mechanobiological modulation of chondrogenic expression

Dominique Pioletti, Philippe Abdel Sayed, Ulrike Kettenberger, Salim Elias Darwiche

Mechanical stimulation has been proposed to induce chondrogenesis in cell-seeded scaffold. However, the effects of mechanical stimuli on engineered cartilage may vary substantially between different scaffolds. This advocates for the need to identify an ove ...

2014

Osteoporosis is a major health problem in our aging society. This metabolic disease, which is characterized by a deterioration of the bone microarchitecture and a significant loss of bone mass, is affecting a rising number of mostly elderly patients. The m ...

EPFL2014

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Bisphosphonates are known for their strong inhibitory effect on bone resorption. Their influence on bone formation however is less clear. In this study we investigated the spatio-temporal effect of locally delivered Zoledronate on peri-implant bone formati ...

Elsevier2014

Polymer or composite microspheres are commonly used for a controlled drug delivery in the human body. The fabrication of those microspheres involves numerous parameters that influence the resulting composition, size and structure of the microspheres. The o ...

2011