Publications de Paolo Paganetti

ER-to-lysosome-associated degradation of proteasome-resistant ATZ polymers occurs via receptor-mediated vesicular transport

Maintenance of cellular proteostasis relies on efficient clearance of defective gene products. For misfolded secretory proteins, this involves dislocation from the endoplasmic reticulum (ER) into the cytosol followed by proteasomal degradation. However, po ...

2018

Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of beta-amyloid-42 aggregation

Andrea Pfeifer, Andreas Muhs, Paolo Paganetti

It is assumed that amyloid-beta aggregation is a crucial event in the pathogenesis of Alzheimer's disease. Novel 2,6-disubstituted pyridine derivatives were designed to interact with the beta-sheet conformation of A beta via donor-acceptor-donor hydrogen b ...

Pergamon-Elsevier Science Ltd2016

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Françoise Gisou van der Goot Grunberg, Maurizio Molinari, Yi Sun, Chong Liu, Giuseppe Russo, Jian Wang, Peng Wang, Wei Chen, Darren Moore, Li Zhang

Taylor & Francis Inc2016

Transgenic expression of beta 1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice

Maurizio Molinari, Paolo Paganetti

Heterologous expression of the functional amyloid beta (A beta) antibody beta 1 in the central nervous system was engineered to maximize antibody exposure in the brain and assess the effects on A beta production and accumulation in these conditions. A sing ...

Elsevier Science Inc2013

Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation

Hilal Lashuel, Andrea Pfeifer, Annalisa Ansaloni, Mohammad Asad Jan Qureshi, Andreas Muhs, Magdalena Zweckstetter, Paolo Paganetti

Increasing evidence implicates Aβ peptides self-assembly and fibril formation as crucial events in the pathogenesis of Alzheimer disease. Thus, inhibiting Aβ aggregation, among others, has emerged as a potential therapeutic intervention for this disorder. ...

Amer Soc Biochemistry Molecular Biology Inc2012

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

Elena Katsyuba, Paolo Paganetti

Huntington disease (HD) is a devastating neurodegenerative disorder for which there are no disease-modifying treatments. Previous studies have proposed that activation of the heat shock response (HSR) via the transcription factor heat shock factor 1 (HSF1) ...

American Society for Clinical Investigation2011