Publications de Viktoria Reinmüller

Enhancers of notch signaling and their use in the treatment of cancers and malignancies medicable by upregulation of notch

The present invention relates to the use for enhancing Notch signaling in an individual, of a compound showing the general formula (I) and/or a pharmaceutically acceptable salt or ester thereof, for the treatment of a disease selected from the group of der ...

2017

Development Of A Novel First-In-Class Oral Inhibitor Of The Notch Pathway

Freddy Radtke, Gerardo Turcatti, Rajwinder Lehal, Viktoria Reinmüller

Ferrata Storti Foundation2016

Lead Optimisation of a Novel Small Molecule Notch Inhibitor

Viktoria Reinmüller

Notch signalling represents a form of cell-to-cell communication that plays a pivotal role for cellular organisation during embryonic and postnatal development, as well as in the homeostasis of adult organs and tissues. Malfunction of this signalling pathw ...

EPFL2015

Inhibitors of notch signalling pathway and use thereof in treatment of cancers

Freddy Radtke, Jieping Zhu, Rajwinder Lehal, Viktoria Reinmüller

The present invention relates to use of inhibitors of Notch signalling pathway selected from the group consisting of 6-(4-Tert-Butylphenoxy)Pyridin-3-Amine (I3), its derivatives, in treating and/or preventing cancers. ...

2013