Francesco Simone Ruggeri

Cette personne n’est plus à l’EPFL

Publications associées (21)

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Nanoscale studies link amyloid maturity with polyglutamine diseases onset

Giovanni Dietler, Hilal Lashuel, Giovanni Longo, Francesco Simone Ruggeri, Urszula Beata Cendrowska

The presence of expanded poly-glutamine (polyQ) repeats in proteins is directly linked to the pathogenesis of several neurodegenerative diseases, including Huntington's disease. However, the molecular and structural basis underlying the increased toxicity ...

Nature Research2016

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

Giovanni Dietler, Francesco Simone Ruggeri

A wide consensus based on robust experimental evidence indicates pyroglutamylated amyloid-beta isoform (A beta pE3-42) as one of the most neurotoxic peptides involved in the onset of Alzheimer's disease. Furthermore, A beta pE3-42 co-oligomerized with exce ...

Elsevier2016

Micro- and nanoscale hierarchical structure of core-shell protein microgels

Giovanni Dietler, Francesco Simone Ruggeri, Raffaele Mezzenga

Protein nanofibrils were first discovered in the context of misfolding and neurodegenerative diseases but have recently been found in naturally occurring functional materials including algal adhesives, bacterial coatings, and even mammalian melanosomes. Th ...

Royal Society of Chemistry2016

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species

Giovanni Dietler, Francesco Simone Ruggeri, Andrea Cerreta

Background: A wide class of human diseases and neurodegenerative disorders, such as Alzheimer's disease, is due to the failure of a specific peptide or protein to keep its native functional conformational state and to undergo a conformational change into a ...

Bentham Science Publishers2016

Concentration-dependent and surface-assisted self-assembly properties of a bioactive estrogen receptor alpha-derived peptide

Giovanni Dietler, Francesco Simone Ruggeri

We have synthesized a 17-mer peptide (ER17p) that is issued from the hinge region of the estrogen receptor and which activates the proliferation of breast carcinoma cells in steroid-deprived conditions. In the present paper, we show that at a concentration ...

Wiley-Blackwell2015

New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

Francesco Simone Ruggeri

Today, more than 40 million people worldwide are affected by neurodegenerative disorders. Onset of these diseases is associated with insoluble fibrillar protein aggregates, termed amyloids. The molecular origin and the link between amyloid formation and di ...

EPFL2015

Detecting nanoscale vibrations as signature of life

Giovanni Dietler, Sandor Kasas, Giovanni Longo, Francesco Simone Ruggeri, Petar Stupar

The existence of life in extreme conditions, in particular in extraterrestrial environments, is certainly one of the most intriguing scientific questions of our time. In this report, we demonstrate the use of an innovative nanoscale motion sensor in life-s ...

National Academy of Sciences2015

Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation

Giovanni Dietler, Giovanni Longo, Francesco Simone Ruggeri, Ewelina Wioletta Lipiec

Amyloids are insoluble protein fibrillar aggregates. The importance of characterizing their aggregation has steadily increased because of their link to human diseases and material science applications. In particular, misfolding and aggregation of the Josep ...

Nature Publishing Group2015

The H50Q Mutation Enhances alpha-Synuclein Aggregation, Secretion, and Toxicity

Giovanni Dietler, Hilal Lashuel, Francesco Simone Ruggeri, Anne-Laure Mahul Mellier, Bruno Claude Daniel Fauvet, Abid Oueslati, Martial Mbefo Kamdem, Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf, Filip Vercruysse

Over the last two decades, the identification of missense mutations in the alpha-synuclein (alpha-Syn) gene SNCA in families with inherited Parkinson disease (PD) has reinforced the central role of alpha-Syn in PD pathogenesis. Recently, a new missense mut ...

American Society for Biochemistry and Molecular Biology2014

Nanoscale spatially resolved infrared spectra from single microdroplets

Giovanni Dietler, Andrzej Kulik, Francesco Simone Ruggeri

Droplet microfluidics has emerged as a powerful platform allowing a large number of individual reactions to be carried out in spatially distinct microcompartments. Due to their small size, however, the spectroscopic characterisation of species encapsulated ...

Royal Society of Chemistry2014

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A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

Giovanni Dietler, Francesco Simone Ruggeri

Elsevier2016

Micro- and nanoscale hierarchical structure of core-shell protein microgels

Giovanni Dietler, Francesco Simone Ruggeri, Raffaele Mezzenga

Royal Society of Chemistry2016

Concentration-dependent and surface-assisted self-assembly properties of a bioactive estrogen receptor alpha-derived peptide

Giovanni Dietler, Francesco Simone Ruggeri

Wiley-Blackwell2015