Publications de Stéphanie Lacour

Direct laser writing of electronically conductive microstructures within soft hydrogel substrates

Stéphanie Lacour, Esther Amstad, Outman Akouissi, Lorenzo Lucherini

Hydrogels have emerged as promising materials for bioelectronic interfaces due to their tissue-like properties and high-water content. However, conventional hydrogels often suffer from poor electrical conductivity and mechanical stability, limiting their p ...

2025

Optogenetic modulation of peripheral nociceptive neurons with biocompatible optoelectronic implants

Stéphanie Lacour, Bernard Schneider, Ivan Furfaro, Frédéric Pierre Gérald Michoud, Valentina Marie Paggi

Hyperexcitability of peripheral sensory neurons plays a critical role in the development and maintenance of chronic pain. Pharmacological analgesics used in clinics reduce neuronal activity. They often come with non‐negligible side effects. Optogenetic app ...

Wiley2025

High-resolution prosthetic hearing with a soft auditory brainstem implant in macaques

Stéphanie Lacour, Jocelyne Bloch, Ivan Furfaro, Florent-Valéry Coen, Alix Esther Anne Trouillet, Emilie Cornelia Maria Revol, Laurine Kolly, Florian Dylan Fallegger

Individuals with compromised cochlear nerves are ineligible for cochlear implants and instead rely on auditory brainstem implants (ABIs). Most users of ABIs experience sound awareness, which aids in lip reading, yet not speech intelligibility. Here we engi ...

2025

Magnesium Optrodes for Real-Time Optical Monitoring of Water Transport in Ultrathin Encapsulations for Bioelectronics

Yves Leterrier, Stéphanie Lacour, Hatice Altug, Deepthy Kavungal, Massimo Mariello

Recent studies investigated the hydrolysis of Magnesium (Mg) thin films, highlighting their potential use in biodegradable devices. Quantitatively monitoring the degradation rate and morphological changes of Mg through optical methods and light-delivery de ...

2024

A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation

Silvestro Micera, Stéphanie Lacour, Katia Galan, Ivan Furfaro, Florian Dylan Fallegger, Valentina Marie Paggi, Olivier Didier Christian Rizzo

Background: Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in discrete circular sizes, complications ...

2024

Water-permeation sensor and method for making the same

Yves Leterrier, Stéphanie Lacour, Kyungjin Kim, Massimo Mariello

A water permeation sensor suitable for monitoring and quantitatively assessing ultra-low permeability of thin film encapsulations engineered for bioelectronic microdevices, its fabrication as well as device comprising the same are disclosed herein. ...

2024

Optical Monitoring of Water Side Permeation in Thin Film Encapsulation

Yves Leterrier, Stéphanie Lacour, Kangling Wu, Massimo Mariello

The stability of long-term microfabricated implants is hindered by the presence of multiple water diffusion paths within artificially patterned thin-film encapsulations. Side permeation, defined as infiltration of molecules through the lateral surface of t ...

Wiley-V C H Verlag Gmbh2024

Hermetic, Hybrid Multilayer, Sub-5µm-Thick Encapsulations Prepared with Vapor-Phase Infiltration of Metal Oxides in Conformal Polymers for Flexible Bioelectronics

Yves Leterrier, Stéphanie Lacour, Kangling Wu, Massimo Mariello

Reliable long-term function is crucial for flexible and soft bioelectronics. Mechanical defects and permeation of water molecules across the various device layers are the prime drivers of failure, and particularly in applications requiring continuous conta ...

2024

Magnesium Test: Universal and Ultra-Sensitive Method for Measuring Reliability of Thin-Film-Encapsulated Bioelectronic Implants in Physiological Environment

Yves Leterrier, Stéphanie Lacour, Grégoire Courtine, Ivan Furfaro, Kangling Wu, Lei Wang, Claudia Kathe, Massimo Mariello

Next-generation bioelectronic implants require miniaturization, durability, and long-term functionality. Thin film encapsulations, prepared with inorganic or hybrid organic/inorganic designs, are essential for ensuring protection, low water permeation, ada ...

Wiley-V C H Verlag Gmbh2024

The e-Flower: A hydrogel-actuated 3D MEA for brain reserved; exclusive licensee American spheroid electrophysiology Association for the Advancement of

Stéphanie Lacour, Ivan Furfaro, Outman Akouissi

Traditional microelectrode arrays (MEAs) are limited to measuring electrophysiological activity in two dimen- Attribution creative commons sions, failing to capture the complexity of three-dimensional (3D) tissues such as neural organoids and spheroids. no ...

2024