Stéphanie Lacour

Publications associées (122)

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Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Giuseppe Schiavone, Tomislav Milekovic, Katia Galan, Nicholas David James, Florian Dylan Fallegger

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

A 16-Channel Neural Recording System-on-Chip With CHT Feature Extraction Processor in 65-nm CMOS

Volkan Cevher, Stéphanie Lacour, Catherine Dehollain, Cosimo Aprile, Alix Esther Anne Trouillet, Emilie Cornelia Maria Revol, Yusuf Leblebici, Kerim Türe, Florian Dylan Fallegger, Arda Uran

Next generation invasive neural interfaces require fully implantable wireless systems that can record from a large number of channels simultaneously. However, transferring the recorded data from the implant to an external receiver emerges as a significant ...

2022

Comparison of Responses to DCN vs. VCN Stimulation in a Mouse Model of the Auditory Brainstem Implant (ABI)

Stéphanie Lacour, Florent-Valéry Coen, Nicolas Vachicouras

The auditory brainstem implant (ABI) is an auditory neuroprosthesis that provides hearing to deaf patients by electrically stimulating the cochlear nucleus (CN) of the brainstem. Whether such stimulation activates one or the other of the CN's two major sub ...

SPRINGER2022

NeuralTree: A 256-Channel 0.227-mu J/Class Versatile Neural Activity Classification and Closed-Loop Neuromodulation SoC

Stéphanie Lacour, Mahsa Shoaran, Uisub Shin, Cong Ding, Alix Esther Anne Trouillet, Emilie Cornelia Maria Revol, Bingzhao Zhu

Closed-loop neural interfaces with on-chip machine learning can detect and suppress disease symptoms in neurological disorders or restore lost functions in paralyzed patients. While high-density neural recording can provide rich neural activity information ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

The neurons that restore walking after paralysis

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Léonie Asboth, Katia Galan, Robin Jonathan Demesmaeker, Nicholas David James, Matthieu Pierre Gautier

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures

Stéphanie Lacour

Cardiomyocyte cultures exhibit spontaneous electrical and contractile activity, as in a natural cardiac pacemaker. In such preparations, beat rate variability exhibits features similar to those of heart rate variability in vivo. Mechanical deformations and ...

WILEY2022

Recent Advances in Encapsulation of Flexible Bioelectronic Implants: Materials, Technologies, and Characterization Methods

Yves Leterrier, Stéphanie Lacour, Kangling Wu, Kyungjin Kim, Massimo Mariello

Bioelectronic implantable systems (BIS) targeting biomedical and clinical research should combine long-term performance and biointegration in vivo. Here, recent advances in novel encapsulations to protect flexible versions of such systems from the surround ...

Wiley-V C H Verlag Gmbh2022

Chronic recording of cortical activit y underlying vocalization in awake minipigs

Stéphanie Lacour, Giuseppe Schiavone, Florian Dylan Fallegger

Background: Investigating brain dynamics underlying vocal production in animals is a powerf u l w a y to inform on the neural bases of human speech. In particular, brain networks underlying vocal production in non-human primates show striking similarities ...

ELSEVIER2022

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

Stéphanie Lacour

Fibrotic scarring secondary to the foreign body reaction (FBR) generates a physical barrier obstructing the functional interaction of implantable medical devices with the host tissue. The mechanistic basis of the FBR is poorly understood, restricting the c ...

National Academy of Sciences2022

Preclinical upper limb neurorobotic platform to assess, rehabilitate, and develop therapies

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Nicholas David James, Florent-Valéry Coen, Selin Anil, Newton Cho

Numerous neurorehabilitative, neuroprosthetic, and repair interventions aim to address the consequences of upper limb impairments after neurological disorders. Although these therapies target widely different mechanisms, they share the common need for a pr ...

AMER ASSOC ADVANCEMENT SCIENCE2022

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Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures

Stéphanie Lacour

WILEY2022

Recent Advances in Encapsulation of Flexible Bioelectronic Implants: Materials, Technologies, and Characterization Methods

Yves Leterrier, Stéphanie Lacour, Kangling Wu, Kyungjin Kim, Massimo Mariello

Wiley-V C H Verlag Gmbh2022

Preclinical upper limb neurorobotic platform to assess, rehabilitate, and develop therapies

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Nicholas David James, Florent-Valéry Coen, Selin Anil, Newton Cho

AMER ASSOC ADVANCEMENT SCIENCE2022