Personne
Dominique Soldati-Favre
Publications associées (6)
Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism
Vassily Hatzimanikatis, Matteo Lunghi, Damien Lionel Nicolas, Anush Chiappino-Pepe, Aarti Krishnan, Dominique Soldati-Favre
To survive and proliferate in diverse host environments with varying nutrient availability, the obligate intracellular parasite Toxoplasma gondii reprograms its metabolism. We have generated and curated a genome-scale metabolic model (iTgo) for the fast-re ...
CELL PRESS2020Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage
Vassily Hatzimanikatis, Vikash Kumar Pandey, Anush Chiappino-Pepe, Dominique Soldati-Favre
Plasmodium gene functions in mosquito and liver stages remain poorly characterized due to limitations in the throughput of phenotyping at these stages. To fill this gap, we followed more than 1,300 barcoded P. berghei mutants through the life cycle. We dis ...
CELL PRESS2019Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks
Vassily Hatzimanikatis, Meriç Ataman, Stepan Tymoshenko, Dominique Soldati-Favre
Novel antimalarial therapies are urgently needed for the fight against drug-resistant para- sites. The metabolism of malaria parasites in infected cells is an attractive source of drug targets but is rather complex. Computational methods can handle this co ...
Public Library of Science2017Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis
Vassily Hatzimanikatis, Stepan Tymoshenko, Rebecca Oppenheim, Jens Nielsen, Dominique Soldati-Favre
Toxoplasma gondii is a human pathogen prevalent worldwide that poses a challenging and unmet need for novel treatment of toxoplasmosis. Using a semi-automated reconstruction algorithm, we reconstructed a genome-scale metabolic model, ToxoNet1. The reconstr ...
Public Library Science2015Developing a Reconciled Genome-Scale Model of the Malaria Parasite Plasmodium falciparum and its Thermodynamics-based Flux Balance Analysis
Vassily Hatzimanikatis, Meriç Ataman, Stepan Tymoshenko, Dominique Soldati-Favre
Understanding the metabolism of the malaria parasites is of high priority to identify novel enzymatic drug targets and face the rise in drug resistant parasites. Based on the knowledge of metabolic functions and molecular interactions, we can reconstruct g ...
2015Functional genomics of Plasmodium falciparum using metabolic modelling and analysis
Vassily Hatzimanikatis, Stepan Tymoshenko, Rebecca Oppenheim, Dominique Soldati-Favre
Plasmodium falciparum is an obligate intracellular parasite and the leading cause of severe malaria responsible for tremendous morbidity and mortality particularly in sub-Saharan Africa. Successful completion of the P. falciparum genome sequencing project ...
Oxford Univ Press2013