Publications de Pierre Vincent Dessen

Metabolic dependencies of metastasis-initiating cells in female breast cancer

Albert Santamaria Martinez, Pierre Vincent Dessen, Jörg Hülsken, Laurent Nam Ky Beziaud, Angela Madurga Alonso, Candice Megan T Young

Understanding the mechanisms that enable cancer cells to metastasize is essential in preventing cancer progression. Here we examine the metabolic adaptations of metastasis-initiating cells (MICs) in female breast cancer and how those shape their metastatic ...

Nature Portfolio2023

Phage selection of chemically stabilized alpha-helical peptide ligands

Christian Heinis, Jörg Hülsken, Pierre Vincent Dessen, Philippe Diderich, Davide Bertoldo, Maola Khan Mohammad Golam

Short alpha-helical peptides stabilized by linkages between constituent amino acids offer an attractive format for ligand development. In recent years, a range of excellent ligands based on stabilized alpha-helices were generated by rational design using a ...

2016

Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling

Christian Heinis, Jörg Hülsken, Pierre Vincent Dessen, Davide Bertoldo, Maola Khan Mohammad Golam

Upregulation of b-catenin, the primary mediator of the Wnt signaling pathway, plays an important role in the tumorigenesis of several types of human cancer. Targeting b-catenin to interfere with its ability to serve as a translational co-activator is consi ...

2016

Successful immunotherapy of cancer stem cells requires memory and the adaptive immune system of the host

Jörg Hülsken, Pierre Vincent Dessen, Patrick Schmidt, Nancy Thompson, Nicolas Pierre Desbaillets

Amer Assoc Cancer Research2016

Successful Immunotherapy of Cancer Stem Cells Requires Memory and the Adaptive Immune System of the Host

Jörg Hülsken, Pierre Vincent Dessen, Patrick Schmidt, Nancy Thompson, Nicolas Pierre Desbaillets

Nature Publishing Group2015