Publications de Jacques Fellay

Deciphering the Foundations of Mitochondrial Mutational Spectra: Replication-Driven and Damage-Induced Signatures Across Chordate Classes

Mitochondrial DNA (mtDNA) mutagenesis remains poorly understood despite its crucial role in disease, aging, and evolutionary tracing. In this study, we reconstructed a comprehensive 192-component mtDNA mutational spectrum for chordates by analyzing 118,397 ...

OXFORD UNIV PRESS2025

Types of Myocardial Infarction in People with HIV in Switzerland

Jacques Fellay

Background Of myocardial infarctions (MI) recorded in two large HIV observational studies from North America, approximately half were classified as type 2. In the REPRIEVE clinical trial of pitavastatin vs. placebo in people with HIV (<3% of participant ...

Oxford University Press (OUP)2025

Leukocyte Count and New-onset Diabetes Mellitus in People with Hiv: a Longitudinal Study

Jacques Fellay

Objectives: The risk of diabetes mellitus (DM) is increased in people with HIV. Chronic inflammation contributes to DM risk. High leukocytes are associated with DM in the general population, but in people with HIV, evidence of a leukocyte-DM association is ...

WILEY2025

Granulysin Antimicrobial Activity Promotes Dormancy in Mycobacterium tuberculosis

Jacques Fellay

Human tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains a global public health threat. Granulomas constitute a hallmark of TB pathogenesis that can clear, contain, or exacerbate an infection. Containment is exploited by Mtb as a hideout ...

2025

Decoding the Interactions and Functions of Non-coding Rna with Artificial Intelligence

Pascal Frossard, Jacques Fellay, Vincent Jung

In addition to encoding proteins, mRNAs have context-specific regulatory roles that contribute to many cellular processes. However, uncovering new mRNA functions is constrained by limitations of traditional biochemical and computational methods. In this Ro ...

NATURE PORTFOLIO2025

Proteome-wide prediction of the mode of inheritance and molecular mechanisms underlying genetic diseases using structural interactomics

Jacques Fellay

Genetic diseases can be classified according to their modes of inheritance and their underlying molecular mechanisms. Autosomal dominant disorders often result from DNA variants that cause loss-of-function, gain-of-function, or dominant-negative effects, w ...

Elsevier BV2025

Fine-tuning protein language models to understand the functional impact of missense variants

Jacques Fellay

Elucidating the functional effects of missense variants is crucial yet challenging. To investigate their impact, we fine-tuned protein language models, including ESM2 and ProtT5, to classify 20 protein features at amino acid resolution. In addition, we tra ...

2025

Low Trauma Fractures in People with Hiv: Longitudinal Time Trends in the Swiss Hiv Cohort Study, 2009-2022

Jacques Fellay, Christian Axel Wandall Thorball

Background People with human immunodeficiency virus (HIV) are at increased risk of low trauma fractures (LTFs). Published data on LTF incidence trends over time have not been uniform. This study sought to analyze LTF time trends in the Swiss HIV Cohort Stu ...

OXFORD UNIV PRESS INC2025

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains

Jacques Fellay

Outbreaks of chilblains were reported during the COVID-19 pandemic. Given the essential role of type I interferon (I-IFN) in protective immunity against SARS-CoV-2 and the association of chilblains with inherited type I interferonopathies, we hypothesized ...

ROCKEFELLER UNIV PRESS2025

Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania

Jacques Fellay, Olivier Noël Marie Naret, Zhi Ming Xu, Dylan Lawless, Sina Rüeger

The risk and prognosis of tuberculosis (TB) are influenced by a complex interplay between human and bacterial genetic factors. While previous genomic studies have largely examined human and bacterial genomes separately, we adopted an integrated approach to ...

Springer Science and Business Media LLC2025