Publications de Alessandro De Simone

PI(4,5)P-2 forms dynamic cortical structures and directs actin distribution as well as polarity in Caenorhabditis elegans embryos

Pierre Gönczy, Alessandro De Simone, Melina Jasmin Scholze

2018

Uncovering the balance of forces driving microtubule aster migration in C. elegans zygotes

Pierre Gönczy, Coralie Busso, Antoine Jérôme Spahr, Alessandro De Simone

Nature Research2018

Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes

Centrosome separation along the surface of the nucleus at the onset of mitosis is critical for bipolar spindle assembly. Dynein anchored on the nuclear envelope is known to be important for centrosome separation, but it is unclear how nuclear dynein forces ...

Amer Soc Cell Biology2017

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

Pierre Gönczy, Alessandro De Simone

The two centrosomes present at the onset of mitosis must separate in a timely and accurate fashion to ensure proper bipolar spindle assembly. The minus-end-directed motor dynein plays a pivotal role in centrosome separation, but the underlying mechanisms r ...

Elsevier2016

Mechanisms of centrosome separation in C. elegans

Alessandro De Simone

Centrosomes are the major microtubule organizing centers of animal cells. The two centrosomes present at the onset of mitosis must separate in a timely fashion along the nuclear envelope to ensure proper bipolar spindle assembly and thus genome stability. ...

EPFL2016

Three-dimensional chemotaxis-driven aggregation of tumor cells

Alessandro De Simone, Andrea Gamba

One of the most important steps in tumor progression involves the transformation from a differentiated epithelial phenotype to an aggressive, highly motile phenotype, where tumor cells invade neighboring tissues. Invasion can occur either by isolated mesen ...

Nature Publishing Group2015

Cortical Dynein Powered by Polarized Actomyosin Contractions and Pronuclear Dynein Separate Centrosomes

Pierre Gönczy, Alessandro De Simone

Cell Press2015

Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos

Pierre Gönczy, Alessandro De Simone, Kalyani Thyagarajan, Sylvain Träger

Regulation of centrosome and spindle positioning is crucial for spatial cell division control. The one-cell Caenorhabditis elegans embryo has proven attractive for dissecting the mechanisms underlying centrosome and spindle positioning in a metazoan organi ...

Company Of Biologists Ltd2014