Publications de Alessandro De Simone

Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes

Centrosome separation along the surface of the nucleus at the onset of mitosis is critical for bipolar spindle assembly. Dynein anchored on the nuclear envelope is known to be important for centrosome separation, but it is unclear how nuclear dynein forces ...

Amer Soc Cell Biology2017

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

Pierre Gönczy, Alessandro De Simone

The two centrosomes present at the onset of mitosis must separate in a timely and accurate fashion to ensure proper bipolar spindle assembly. The minus-end-directed motor dynein plays a pivotal role in centrosome separation, but the underlying mechanisms r ...

Elsevier2016

Three-dimensional chemotaxis-driven aggregation of tumor cells

Alessandro De Simone, Andrea Gamba

One of the most important steps in tumor progression involves the transformation from a differentiated epithelial phenotype to an aggressive, highly motile phenotype, where tumor cells invade neighboring tissues. Invasion can occur either by isolated mesen ...

Nature Publishing Group2015

Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos

Pierre Gönczy, Alessandro De Simone, Sylvain Träger, Kalyani Thyagarajan

Regulation of centrosome and spindle positioning is crucial for spatial cell division control. The one-cell Caenorhabditis elegans embryo has proven attractive for dissecting the mechanisms underlying centrosome and spindle positioning in a metazoan organi ...

Company Of Biologists Ltd2014

Analysis of precision in chemical oscillators: implications for circadian clocks

Felix Naef, Alessandro De Simone, Thomas d'Eysmond

Biochemical reaction networks often exhibit spontaneous self-sustained oscillations. An example is the circadian oscillator that lies at the heart of daily rhythms in behavior and physiology in most organisms including humans. While the period of these osc ...

Institute of Physics2013

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Alessandro De Simone

Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes

Mechanisms of centrosome separation in C. elegans

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

Three-dimensional chemotaxis-driven aggregation of tumor cells

Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos

Analysis of precision in chemical oscillators: implications for circadian clocks

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Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos

Analysis of precision in chemical oscillators: implications for circadian clocks

Mechanisms of centrosome separation in C. elegans

Three-dimensional chemotaxis-driven aggregation of tumor cells