Recherche

Afficher tous les résultats pour

Accueil

Personne

Maroun Bou Sleiman

Cette personne n’est plus à l’EPFL

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (35)

Article Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

Johan Auwerx, Maroun Bou Sleiman, Wen Gao, Yang Li, Amélia Lalou, Gaby El Alam

The mitochondrial unfolded protein response (UPRmt) is a promising pharmacological target for aging and age-related diseases. However, the integrative analysis of the impact of UPRmt activation on different signaling layers in animals with different geneti ...

CELL PRESS2022

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

Johan Auwerx, Davide D'Amico, Tanes Imamura de Lima, Qi Wang, Sébastien Robert Victor Herzig, Maroun Bou Sleiman, Martin Rainer Wohlwend, Peiling Luan, Pirkka-Pekka Untamo Laurila, Barbara Moreira Crisol

Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse skeletal muscle upon aging and that both genetic a ...

2022

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Giacomo Vincenzo Giorgio Von Alvensleben, Hao Li, Maroun Bou Sleiman, Karim Laurent Gariani, Laura Alejandra Velazquez Villegas, Ludger Jan Elzuë Goeminne

Bile acids (BAs) are complex and incompletely understood enterohepatic-derived hormones that control whole-body metabolism. Here, we profiled postprandial BAs in the liver, feces, and plasma of 360 chowor high-fat-diet-fed BXD male mice and demonstrated th ...

Cell Press2022

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

Johan Auwerx, Sandra Rodriguez Lopez, Maroun Bou Sleiman, Pooja Jha, Martin Rainer Wohlwend, Pirkka-Pekka Untamo Laurila, Ludger Jan Elzuë Goeminne

Benegiamo et al. identify genetic variants of the mitochondrial supercomplex assembly factor COX7A2L in the skeletal muscle of mice and humans that promote cardiorespiratory fitness. ...

NATURE PORTFOLIO2022

The Genetic Background Shapes Disease Susceptibility And Reveals A Specific Role For Mitochondrial Dysfunction In The Progression From Nafld To Nash

Johan Auwerx, Jia Liu, Sandra Rodriguez Lopez, Giacomo Vincenzo Giorgio Von Alvensleben, Maroun Bou Sleiman, Alexis Maximilien Bachmann, Jean-David Horacio Morel

WILEY2022

Gene-by-environment modulation of lifespan and weight gain in the murine BXD family

Johan Auwerx, Maroun Bou Sleiman, Evan Graehl Williams, Pooja Jha

How lifespan and body weight vary as a function of diet and genetic differences is not well understood. Here we quantify the impact of differences in diet on lifespan in a genetically diverse family of female mice, split into matched isogenic cohorts fed a ...

NATURE PORTFOLIO2021

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

Maroun Bou Sleiman

Identification of gene expression changes between healthy and diseased individuals can reveal mechanistic insights and biomarkers. Here, the authors propose a bi-directional transcriptome-wide Mendelian Randomization approach to assess causal effects betwe ...

Nature Research2021

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Johan Auwerx, Richardus Houtkooper, Maroun Bou Sleiman, Xu Wang, Pooja Jha

Many genes and pathways have been linked to aging, yet our understanding of underlying molecular mechanisms is still lacking. Here, we measure changes in the transcriptome, histone modifications, and DNA methylome in three metabolic tissues of adult and ag ...

2020

cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel

Bart Deplancke, Vincent Roland Julien Gardeux, Maroun Bou Sleiman, Virginie Sandra Braman, Riccardo Dainese, Maria Litovchenko, Michael Vincent Frochaux, Dani Osman, Brian Dennis Hollis, Tommaso Andreani

Background: Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understan ...

2020

Enteric infection induces Lark-mediated intron retention at the 5 ' end of Drosophila genes

Bart Deplancke, Maroun Bou Sleiman, Michael Vincent Frochaux, Dani Osman, Tommaso Andreani

Background RNA splicing is a key post-transcriptional mechanism that generates protein diversity and contributes to the fine-tuning of gene expression, which may facilitate adaptation to environmental challenges. Here, we employ a systems approach to study ...

2020

Page 2 sur 4

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

2022

cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel

2020

Article Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

Johan Auwerx, Maroun Bou Sleiman, Wen Gao, Yang Li, Amélia Lalou, Gaby El Alam

CELL PRESS2022

The Genetic Background Shapes Disease Susceptibility And Reveals A Specific Role For Mitochondrial Dysfunction In The Progression From Nafld To Nash

Johan Auwerx, Jia Liu, Sandra Rodriguez Lopez, Giacomo Vincenzo Giorgio Von Alvensleben, Maroun Bou Sleiman, Alexis Maximilien Bachmann, Jean-David Horacio Morel

WILEY2022

NATURE PORTFOLIO2022