Publications de Reto Frei | EPFL Graph Search

General and Practical Formation of Thiocyanates from Thiols

Jérôme Waser, Matthew Wodrich, Reto Frei, Thibaut Christian Courant

A new method for the cyanation of thiols and disulfides using cyanobenziodoxol(on)e hypervalent iodine reagents is described. Both aliphatic and aromatic thiocyanates can be accessed in good yields in a few minutes at room temperature starting from a broad ...

Wiley-Blackwell2015

Proteome-Wide Profiling of Targets of Cysteine reactive Small Molecules by Using Ethynyl Benziodoxolone Reagents

Jérôme Waser, Chao Wang, Reto Frei, Durga Prasada Rao Hari

In this study, we present a highly efficient method for proteomic profiling of cysteine residues in complex proteomes and in living cells. Our method is based on alkynylation of cysteines in complex proteomes using a clickable alkynyl benziodoxolone bearin ...

Wiley-Blackwell2015

Performance of the LHCb Vertex Locator

Olivier Schneider, Aurelio Bay, Guido Haefeli, Barinjaka Rakotomiaramanana, Jian Wang, Mark Tobin, Matthew Needham, Reto Frei

The Vertex Locator (VELO) is a silicon microstrip detector that surrounds the proton-proton interaction region in the LHCb experiment. The performance of the detector during the first years of its physics operation is reviewed. The system is operated in va ...

Iop Publishing Ltd2014

Taming Hypervalent Bonds and Strained Rings for Catalysis and Synthesis

Jérôme Waser, Reto Frei, Florian Patrick Marie Daniel De la Barre De Nanteuil, Yifan Li, Sophie Lucie Racine, Maria Victoria Vita, Eloísa Sofía Serrano Robledo

Improving the synthesis of complex organic molecules is essential for progress in many fields such as medicine, agrochemicals or materials. Since 2007, our laboratory has been focusing on the development of non-classical bond disconnections based on the us ...

2014

Cyclization and annulation reactions of nitrogen-substituted cyclopropanes and cyclobutanes

Jérôme Waser, Reto Frei, Fides Benfatti, Florian Patrick Marie Daniel De la Barre De Nanteuil, Filippo De Simone, Eloísa Sofía Serrano Robledo

Cyclization and annulation reactions initiated by ring-opening of small rings, especially cyclopropanes and cyclobutanes are now well-established in synthetic chemistry. Nevertheless, the potential of aminocyclopropanes and cyclobutanes, an important subcl ...

Royal Society of Chemistry2014

Fast and Highly Chemoselective Alkynylation of Thiols with Hypervalent Iodine Reagents Enabled through a Low Energy Barrier Concerted Mechanism

Jérôme Waser, Matthew Wodrich, Reto Frei, Durga Prasada Rao Hari

Among all functional groups, alkynes occupy a privileged position in synthetic and medicinal chemistry, chemical biology, and materials science. Thioalkynes, in particular, are highly useful, as they combine the enhanced reactivity of the triple bond with ...

2014

Introducing the CTA concept

Mathieu Ribordy, Steve Couturier, Thomas Günther Bretz, Werner Lustermann, Christophe Bauer, Francisco Sanchez, Xiaoqing Zhou, Reto Frei, Etienne Antoine Julien Moulin, Michael Werner

The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span abou ...

Elsevier Science Bv2013

A Highly Chemoselective and Practical Alkynylation of Thiols

Jérôme Waser, Reto Frei

A thiol-alkynylation procedure utilizing the hypervalent iodine alkyne transfer reagent TIPS-ethynyl-benziodoxolone has been developed. This scalable reaction proceeds in five minutes at room temperature in an open flask using commercially available reagen ...

American Chemical Society2013

Acoustic resonant sensor for ultra high energy neutrino detection

Mathieu Ribordy, Reto Frei

The characterization of the cosmogenic neutrino flux would give insights into cosmological source evolution, source spectra and composition at injection, through the partial recovery of the degraded information carried by the ultra high energy cosmic rays. ...

2011

Performance of the LHCb Silicon Tracker in p-p Collisions at the LHC

Olivier Schneider, Aurelio Bay, Guido Haefeli, Frédéric Blanc, Tatsuya Nakada, Michel De Cian, Raluca Anca Muresan, Johan Luisier, Christophe Salzmann, Mark Tobin

The Large Hadron Collider beauty experiment (LHCb) is a single-arm forward spectrometer dedicated to the study of B-meson decays in p - p collisions at the Large Hadron Collider (LHC). The LHCb detector has excellent tracking and particle identification ca ...

Ieee2011