Publications de Martin Kussmann

Nutrient efficiency at the core of nutrition and sustainability

Martin Kussmann, Christian Nils Raymond Schwab

Frontiers Media Sa2024

Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver

Felix Naef, Loïc Dayon, Jingkui Wang, Frédéric Bruno Martin Gachon, Martin Kussmann, Daniel Alain Dominique Marie Mauvoisin, Florian Atger, Federico Sizzano

Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies with daily environmental cycles. While available techniques yielded crucial insights into regulatio ...

Cell Press2017

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome

Felix Naef, Carlos Canto Alvarez, Jingkui Wang, Loïc Dayon, Frédéric Bruno Martin Gachon, Martin Kussmann, Daniel Alain Dominique Marie Mauvoisin, Joanna Ratajczak, Sebastiano Collino, Florian Atger

Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is t ...

Elsevier2017

Blood Plasma Lipidomic Signature of Epicardial Fat in Healthy Obese Women

Martin Kussmann, Sebastiano Collino

ObjectivesA lipidomic approach was employed in a clinically well-defined cohort of healthy obese women to explore blood lipidome phenotype ascribed to body fat deposition, with emphasis on epicardial adipose tissue (EAT). MethodsThe present investigation d ...

Wiley-Blackwell2015

Proteomics of Cerebrospinal Fluid: Throughput and Robustness Using a Scalable Automated Analysis Pipeline for Biomarker Discovery

Loïc Dayon, Martin Kussmann

Cerebrospinal fluid (CSF) is a body fluid of high clinical relevance and an important source of potential biomarkers for brain-associated damages, such as traumatic brain injury and stroke, and for brain diseases, such as Alzheimer's and Parkinson's. Herei ...

Amer Chemical Soc2015

Proteomics and circadian rhythms: It's all about signaling!

Loïc Dayon, Frédéric Bruno Martin Gachon, Martin Kussmann, Daniel Alain Dominique Marie Mauvoisin

Proteomic technologies using MS offer new perspectives in circadian biology, in particular the possibility to study PTMs. To date, only very few studies have been carried out to decipher the rhythmicity of protein expression in mammals with large-scale pro ...

Wiley-Blackwell2015

Comprehensive and Scalable Highly Automated MS-Based Proteomic Workflow for Clinical Biomarker Discovery in Human Plasma

Loïc Dayon, Martin Kussmann

Over the past decade, mass spectrometric performance has greatly improved in terms of sensitivity, dynamic range, and speed. By contrast, only limited progress has been accomplished with regard to automation, throughput, and robustness of the proteomic sam ...

Amer Chemical Soc2014

Reprint of: Musculoskeletal system in the old age and the demand for healthy ageing biomarkers

Martin Kussmann, Sofia Moco, Sebastiano Collino

Population ageing has emerged as a major demographic trend worldwide due to improved health and longevity. This global ageing phenomenon will have a major impact on health-care systems worldwide due to increased morbidity and greater needs for hospitalizat ...

Elsevier Ireland Ltd2014

Vitamin E and Vitamin E Acetate Absorption from Self-assembly Systems under Pancreas Insufficiency Conditions

Martin Kussmann

We determined the bioavailability of vitamin E from self-assembly structures in patients with diagnosed chronic pancreas insufficiency. Vitamin E solubilized in dispersed inverted bicontinuous cubic phase and in micellar formulation was delivered directly ...

Swiss Chemical Soc2014

Systems Biology Approaches for Inflammatory Bowel Disease: Emphasis on Gut Microbial Metabolism

Martin Kussmann, Sofia Moco

Although the prevalence of main idiopathic forms of inflammatory bowel disease (IBD) has risen considerably over the last decades, their clinical features do not allow accurate prediction of prognosis, likelihood of disease progression, or response to spec ...

Lippincott Williams & Wilkins2014