Personne
David Scott Wilson
Cette personne n’est plus à l’EPFL
Publications associées (6)
Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers
Marcela Rincón-Restrepo, Melody Swartz, Witold Waldemar Kilarski, Sachiko Hirosue, Alexandre de Titta, Esra Güç, David Scott Wilson
Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...
NATURE PUBLISHING GROUP2020Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity
Xavier Fredy René Quaglia-Thermes, Giacomo Olimpio Diaceri, Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Laura Jeanbart, David Scott Wilson, Maria Anna Sofia Broggi, Michal Mateusz Raczy, Ruyi Wang
Fully effective vaccines for complex infections must elicit a diverse repertoire of antibodies (humoral immunity) and CD8+ T-cell responses (cellular immunity). Here, we present a synthetic glyco-adjuvant named p(Man-TLR7), which, when conjugated to antige ...
NATURE PUBLISHING GROUP2019Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes
Xavier Fredy René Quaglia-Thermes, Giacomo Olimpio Diaceri, Jeffrey Alan Hubbell, Sachiko Hirosue, David Scott Wilson, Martina Damo, Michal Mateusz Raczy
Homeostatic antigen presentation by hepatic antigen-presenting cells, which results in tolerogenic T-cell education, could be exploited to induce antigen-specific immunological tolerance. Here we show that antigens modified with polymeric forms of either N ...
2019Glycotargeting therapeutics
Jeffrey Alan Hubbell, David Scott Wilson
Several embodiments of the present disclosure relate to therapeutic compositions configured to target the liver of a subject and that are useful in the treatment or prevention of one or more of transplant rejection, autoimmune disease, food allergy, and im ...
2018Glycotargeting therapeutics
Jeffrey Alan Hubbell, David Scott Wilson
Several embodiments of the present disclosure relate to glycotargeting therapeutics that are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the com ...
2017TLR-3 stimulation improves anti-tumor immunity elicited by dendritic cell exosome-based vaccines in a murine model of melanoma
Eleonora Simeoni, Jeffrey Alan Hubbell, David Scott Wilson, Martina Damo
Dendritic cell (DC)-derived exosomes (Dexo) contain the machinery necessary to activate potent antigen-specific immune responses. As promising cell-free immunogens, Dexo have been tested in previous clinical trials for cancer vaccine immunotherapy, yet res ...
Nature Publishing Group2015