Publications de Alicia Carine Bornert

Traction Forces Control Cell-Edge Dynamics and Mediate Distance Sensitivity during Cell Polarization

Alexander Verkhovskiy, Franck Claude Raynaud, Alicia Carine Bornert, Zeno Messi

Traction forces are generated by cellular actin-myosin system and transmitted to the environment through adhesions. They are believed to drive cell motion, shape changes, and extracellular matrix remodeling [1 -3] . However, most of the traction force anal ...

2020

Traction forces mediate distance-sensitivity to control cell-edge activity during cell polarization

Alexander Verkhovskiy, Franck Claude Raynaud, Alicia Carine Bornert, Zeno Messi

AMER SOC CELL BIOLOGY2018

Minimal model for spontaneous cell polarization and edge activity in oscillating, rotating and migrating cells

Jean-Jacques Meister, Chiara Gabella, Alexander Verkhovskiy, Franck Claude Raynaud, Alicia Carine Bornert, Mark Etienne Ambühl

How cells break symmetry and organize activity at their edges to move directionally is a fundamental question in cell biology. Physical models of cell motility commonly incorporate gradients of regulatory proteins and/or feedback from the motion itself to ...

Nature Publishing Group2016

Protrusion-retraction switches and traction forces in spontaneous cell polarization

Alicia Carine Bornert

Cell migration is a fundamental property of all animal cells which is involved in processes such as embryogenesis, immune response, tissue regeneration and cancer metastasis. Directional migration requires cell polarization which could happen in response t ...

EPFL2016

Contact Angle at the Leading Edge Controls Cell Protrusion Rate

László Forró, Jean-Jacques Meister, Niccolo Piacentini, Chiara Gabella, Alexander Verkhovskiy, Sylvia Jeney, Elena Bertseva, Alicia Carine Bornert

Plasma membrane tension and the pressure generated by actin polymerization are two antagonistic forces believed to define the protrusion rate at the leading edge of migrating cells [1-5]. Quantitatively, resistance to actin protrusion is a product of membr ...

Elsevier2014