Personne
Hongbo Zhang
Cette personne n’est plus à l’EPFL
Publications associées (15)
NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle
Johan Auwerx, Mario Romani, Tanes Imamura de Lima, Hao Li, Vincenzo Sorrentino, Hongbo Zhang
Aging is characterized by loss of proteostasis and mitochondrial homeostasis. Here, we provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways in muscle aging and diseases. Moreover, we show accumulation of amyloid-like d ...
2021The gut microbiota influences skeletal muscle mass and function in mice
Johan Auwerx, Hongbo Zhang, Walter Wahli
The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ-free mice that lacked a gut microbiota to the skeletal muscle of pathogen-free ...
AMER ASSOC ADVANCEMENT SCIENCE2019Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity
Johan Auwerx, Davide D'Amico, Adrian Schmid, Norman Lionel Moullan, Vincenzo Sorrentino, Hongbo Zhang, Francesca Potenza, Solene Rietsch
Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-beta peptide. However, we know relatively little about the underlying molecular mechanisms or how to treat patients with Alzheimer's disease. Here we provid ...
Nature Publishing Group2017Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease
Johan Auwerx, Kristina Schoonjans, Alessia Perino, Vera Monica Lemos Da Silva, Jun Yong Kim, Dongryeol Ryu, Elena Katsyuba, Hongbo Zhang, Keir Joe Menzies, Matthias Alexander Sokrates Stein, Karim Laurent Gariani, Pooja Jha
Background & Aims: To date, no pharmacological therapy has been approved for non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the therapeutic potential of poly ADP-ribose polymerase (PARP) inhibitors in mouse models o ...
Elsevier Science Bv2017Agents and methods using thereof for the prevention and treatment of stem cells senescence
Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies
The present invention relates to agents that prevent or reverse process of stem cell senescence. Further, the invention relates to methods and compositions useful in the prevention and/or treatment of stem senescence. ...
2017Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders
Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies
Abstract of the invention: The present invention relates to agents that induce mitochondrial unfolded protein response (UPR mt ) in muscle stem cells and prevents or reverse process of muscle stem cell senescence. Further, the invention relates to methods ...
2017Metabolic control of muscle and muscle stem cell function
Skeletal muscle composed of myofibers and a small amount of muscle stem cells (MuSCs). It plays important roles in energy metabolism. Some of the key metabolites, such as NAD+ and acetyl-CoA were recently found to regulate muscle and MuSCs function. Most o ...
EPFL2016Protein acetylation in metabolism - metabolites and cofactors
Johan Auwerx, Elena Katsyuba, Hongbo Zhang, Keir Joe Menzies
Reversible acetylation was initially described as an epigenetic mechanism regulating DNA accessibility. Since then, this process has emerged as a controller of histone and nonhistone acetylation that integrates key physiological processes such as metabolis ...
Nature Publishing Group2016KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response
The endoplasmic reticulum (ER) unfolded protein response (UPR(er)) pathway plays an important role in helping pancreatic β cells to adapt their cellular responses to environmental cues and metabolic stress. Although altered UPR(er) gene expression appears ...
Elsevier2016NAD(+) repletion improves muscle function in muscular dystrophy and counters global PARylation
Johan Auwerx, Carlos Canto Alvarez, Laurent Mouchiroud, Dongryeol Ryu, Xu Wang, Vincenzo Sorrentino, Hongbo Zhang, Keir Joe Menzies, Karim Laurent Gariani
Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, we observed correlations between the abundance of mRNA transcripts related to ...
Amer Assoc Advancement Science2016