Publications de Janine Beauparlant

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Grégoire Courtine, Bernard Schneider, Quentin Barraud, Léonie Asboth, Mark Andrew Anderson, Lucia Florinda Friedli Wittler, Laetitia Danielle Philippine Baud, Polina Shkorbatova, Janine Beauparlant, Galyna Pidpruzhnykova

Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished ...

2018

Engagement of the Rat Hindlimb Motor Cortex across Natural Locomotor Behaviors

Silvestro Micera, Grégoire Courtine, Rubia van den Brand, Jacopo Rigosa, Julie Kreider, Lucia Florinda Friedli Wittler, Janine Beauparlant, Simone Ellen Joze Duis

Contrary to cats and primates, cortical contribution to hindlimb locomotor movements is not critical in rats. However, the importance of the motor cortex to regain locomotion after neurological disorders in rats suggests that cortical engagement in hindlim ...

Soc Neuroscience2016

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

José del Rocio Millán Ruiz, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Eduardo Martin Moraud, Pavel Musienko, Nikolaus Wenger, Ivan Rusev Minev, Marco Bonizzato, Janine Beauparlant

In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We spe ...

Elsevier2014

Neuroprosthetic rehabilitation and use-dependent plasticity following severe spinal cord injury

Janine Beauparlant

EPFL2014

Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

Grégoire Courtine, Quentin Barraud, Pavel Musienko, Rubia van den Brand, Lucia Florinda Friedli Wittler, Janine Beauparlant

Severe spinal cord injury in humans leads to a progressive neuronal dysfunction in the chronic stage of the injury. This dysfunction is characterized by premature exhaustion of muscle activity during assisted locomotion, which is associated with the emerge ...

Oxford University Press2013

A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits

Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Stanisa Raspopovic, Pavel Musienko, Nikolaus Wenger, Janine Beauparlant

Epidural electrical stimulation (EES) of lumbosacral segments can restore a range of movements after spinal cord injury. However, the mechanisms and neural structures through which EES facilitates movement execution remain unclear. Here, we designed a comp ...

Society for Neuroscience2013

Multisystem Neuroprosthetic Training Improves Bladder Function After Severe Spinal Cord Injury

Grégoire Courtine, Janine Beauparlant, Rubia van den Brand, Daniel Eberli

Severe spinal cord injury leads to neurogenic bladder dysfunction. We recently developed a multisystem neuroprosthetic training program that promotes plastic changes capable of restoring refined locomotion in rats with severe spinal cord injury. We investi ...

Elsevier Science Inc2013

Response to Comment on "Restoring Voluntary Control of Locomotion After Paralyzing Spinal Cord Injury"

Grégoire Courtine, Janine Beauparlant, Rubia van den Brand

Slawinska et al. questioned the involvement of supraspinal centers in restoring locomotion after multisystem neuroprosthetic training in rats with paralyzing spinal cord injury. Here, we clarify misconceptions and present additional results illustrating th ...

American Association for the Advancement of Science2012