Publications de Virginija Jovaisaite

Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA

Although all Type II restriction endonucleases catalyze phosphodiester bond hydrolysis within or close to their DNA target sites, they form different oligomeric assemblies ranging from monomers, dimers, tetramers to higher order oligomers to generate a dou ...

Oxford University Press (OUP)2017

Joint mouse-human phenome-wide association to test gene function and disease risk

Johan Auwerx, Zhi Li, Evan Graehl Williams, Xu Wang, Virginija Jovaisaite

Phenome-wide association is a novel reverse genetic strategy to analyze genome-to-phenome relations in human clinical cohorts. Here we test this approach using a large murine population segregating for similar to 5 million sequence variants, and we compare ...

Nature Publishing Group2016

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

Johan Auwerx, Laurent Mouchiroud, Evan Graehl Williams, Virginija Jovaisaite

Across eukaryotic species, mild mitochondrial stress can have beneficial effects on the lifespan of organisms. Mitochondrial dysfunction activates an unfolded protein response (UPR(mt)), a stress signaling mechanism designed to ensure mitochondrial homeost ...

Cell Press2016

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

Johan Auwerx, Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Alexis Pierre Henri Marette, Virginija Jovaisaite, Shreya Narasimhan

Studies of the real-time dynamics of embryonic development require a gentle embryo handling method, the possibility of long-term live imaging during the complete embryogenesis, as well as of parallelization providing a population's statistics, while keepin ...

Nature Publishing Group2015

Multi-dimensional imaging and phenotyping of C. elegans embryos via an automated microfluidic device

Johan Auwerx, Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Alexis Pierre Henri Marette, Virginija Jovaisaite, Shreya Narasimhan

We introduce a microfluidic platform for automated on-chip worm culture, creation of synchronized embryo microarrays, and long-term parallel live imaging of Caenorhabditis elegans embryos. Our device allows studying well-defined embryo populations at unpre ...

2015

The mitochondrial unfolded protein response - synchronizing genomes

Johan Auwerx, Virginija Jovaisaite

Maintenance of the mitochondrial proteome is performed primarily by chaperones, which fold and assemble proteins, and by proteases, which degrade excess damaged proteins. Upon various types of mitochondrial stress, triggered genetically or pharmacologicall ...

Current Biology Ltd2015

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

Johan Auwerx, Laurent Mouchiroud, Pénélope Andreux, Richardus Houtkooper, Xu Wang, Norman Lionel Moullan, Adrienne Joëlle Laurence Mottis, Virginija Jovaisaite, Sabrina Bichet

Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular homeostasis, their identification and validation has pro ...

Nature Publishing Group2014

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

Johan Auwerx, Evan Graehl Williams, Adrienne Joëlle Laurence Mottis, Virginija Jovaisaite, Ruedi Aebersold, Sébastien Dubuis

The manner by which genotype and environment affect complex phenotypes is one of the fundamental questions in biology. In this study, we quantified the transcriptome--a subset of the metabolome--and, using targeted proteomics, quantified a subset of the li ...

Cell Press2014

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Virginija Jovaisaite

Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA

Mitochondrial unfolded protein response, its molecular mechanism and physiological impact

Joint mouse-human phenome-wide association to test gene function and disease risk

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

Multi-dimensional imaging and phenotyping of C. elegans embryos via an automated microfluidic device

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

The mitochondrial unfolded protein response - synchronizing genomes

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

Graph Chatbot

Chattez avec Graph Search

The mitochondrial unfolded protein response - synchronizing genomes

Mitochondrial unfolded protein response, its molecular mechanism and physiological impact

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

Multi-dimensional imaging and phenotyping of C. elegans embryos via an automated microfluidic device

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA

Joint mouse-human phenome-wide association to test gene function and disease risk