Publications de Jérome Feige | EPFL Graph Search

Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia

Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD(+)) levels are hallmarks of skeletal muscle ageing and sarcopenia(1,2,3), but it is unclear whether these defects result from local changes or can be mediated by systemic or dietary c ...

2024

Evidence for inefficient contraction and abnormal mitochondrial activity in sarcopenia using magnetic resonance spectroscopy

Jérome Feige

BackgroundMitochondrial dysfunction has been implicated in sarcopenia. P-31 magnetic resonance spectroscopy (MRS) enables non-invasive measurement of adenosine triphosphate (ATP) synthesis rates to probe mitochondrial function. Here, we assessed muscle ene ...

2023

In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

Patrick Descombes, Jérome Feige, Sylviane Métairon, Omid Mashinchian, Filippo De Franceschi, Nicolas Bouche, Christophe Boss

Sustained exposure to a young systemic environment rejuvenates aged organisms and promotes cellular function. However, due to the intrinsic complexity of tissues it remains challenging to pinpoint niche-independent effects of circulating factors on specifi ...

2022

An engineered multicellular stem cell niche for the 3D derivation of human myogenic progenitors from iPSCs

Matthias Lütolf, Omid Mashinchian, Jérome Feige

Fate decisions in the embryo are controlled by a plethora of microenvironmental interactions in a three-dimensional niche. To investigate whether aspects of this microenvironmental complexity can be engineered to direct myogenic human-induced pluripotent s ...

WILEY2022

Nicotinamide riboside kinases regulate skeletal muscle fiber-type specification and are rate-limiting for metabolic adaptations during regeneration

Carlos Canto Alvarez, Jérome Feige

Nicotinamide riboside kinases (NRKs) control the conversion of dietary Nicotinamide Riboside (NR) to NAD(+), but little is known about their contribution to endogenous NAD(+) turnover and muscle plasticity during skeletal muscle growth and remodeling. Usin ...

FRONTIERS MEDIA SA2022

A review of the biomedical innovations for healthy longevity

Jérome Feige

Impact Journals Llc2017

Increasing the Perspectives of Engineering Undergraduates on Societal Issues through an Interdisciplinary Program

Ambrogio Fasoli, Denis Gillet, Alexis Berne, Roland John Tormey, Ingrid Le Duc, Siara Ruth Isaac, Samuel Bendahan, Isabelle Barbara Marie-Hélène Cardia, Delphine Preissmann, Luca Bragazza

To tackle the challenges of the 21st century, future scientists and engineers have to understand the interplay between societal challenges and technical solutions as early as possible in their education. They also have to develop the communication and the ...

Tempus Publications2016