Publications de Flavia Aurelia Shoko Hodel

Prevalence of actionable pharmacogenetic variants in a Swiss hospital cohort

Jacques Fellay, Christian Axel Wandall Thorball, Flavia Aurelia Shoko Hodel, Maria De Min

Springernature2024

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy

Jacques Fellay, Flavia Aurelia Shoko Hodel

Infectious agents contribute significantly to the global burden of diseases through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 ...

2024

Prevalence of actionable pharmacogenetic variants and high-risk drug prescriptions: A Swiss hospital-based cohort study

Jacques Fellay, Christian Axel Wandall Thorball, Flavia Aurelia Shoko Hodel

Drug type and dosing recommendation have been designed and optimized based on average response in the general population. Yet, there is significant inter-individual variability in drug response, which results in treatment inefficacy or adverse drug reactio ...

WILEY2024

Associations of genetic and infectious risk factors with coronary heart disease

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Axel Wandall Thorball, Zhi Ming Xu, Roxane De La Harpe

Coronary heart disease (CHD) is one of the most pressing health problems of our time and a major cause of preventable death. CHD results from complex interactions between genetic and environmental factors. Using multiplex serological testing for persistent ...

eLIFE SCIENCES PUBL LTD2023

Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype

Michael Herzog, Jacques Fellay, Janir Nuno Ramos Antunes Da Cruz, Flavia Aurelia Shoko Hodel, Albulena Jashari-Shaqiri

Schizophrenia is a severe psychiatric disorder determined by a complex mixture of genetic and environmental factors. To better understand the contributions of human genetic variations to schizophrenia, we performed a genome-wide association study (GWAS) of ...

2022

The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

Flavia Aurelia Shoko Hodel

Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...

EPFL2022

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Jacques Fellay, Olivier Noël Marie Naret, Flavia Aurelia Shoko Hodel, Clara Bonnet

Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic low-grade inflammation. There remains an incomple ...

BMC2022

Improving polygenic prediction with genetically inferred ancestry

Jacques Fellay, Olivier Noël Marie Naret, Flavia Aurelia Shoko Hodel, Zhi Ming Xu

Genome-wide association studies (GWASs) have demonstrated that most common diseases have a strong genetic component from many genetic variants each with a small effect size. GWAS summary statistics have allowed the construction of polygenic scores (PGSs) e ...

ELSEVIER2022

Human genomics of the humoral immune response against polyomaviruses

Jacques Fellay, Christian Axel Wandall Thorball, Olivier Noël Marie Naret, Christian Hammer, Flavia Aurelia Shoko Hodel, Zhi Ming Xu, Petar Scepanovic

Human polyomaviruses are widespread in humans and can cause severe disease in immunocompromised individuals. To identify human genetic determinants of the humoral immune response against polyomaviruses, we performed genome-wide association studies and meta ...

OXFORD UNIV PRESS2021

Human genomics of the humoral response against polyomaviruses

Jacques Fellay, Christian Axel Wandall Thorball, Christian Hammer, Flavia Aurelia Shoko Hodel, Zhi Ming Xu, Petar Scepanovic

SPRINGERNATURE2020