Hatice Altug

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Publications associées (123)

Nanoplasmonic Single-Tumoroid Microarray for Real-Time Secretion Analysis

Hatice Altug, Nicolas Antoine Vincent Broguiere, Yen-Cheng Liu, Saeid Ansaryan, Luis Francisco Lorenzo Martin

Organoid tumor models have emerged as a powerful tool in the fields of biology and medicine as such 3D structures grown from tumor cells recapitulate better tumor characteristics, making these tumoroids unique for personalized cancer research. Assessment o ...

2024

Spectral Tuning of High-Harmonic Generation with Resonance-Gradient Metasurfaces

Hatice Altug, Felix Ulrich Richter

High-index dielectric subwavelength structures and metasurfaces are capable of enhancing light-matter interaction by orders of magnitude via geometry-dependent optical resonances. This enhancement, however, comes with a fundamental limitation of a narrow s ...

Wiley-V C H Verlag Gmbh2023

High-throughput spatiotemporal monitoring of single-cell secretions via plasmonic microwell arrays

Hatice Altug, Yen-Cheng Liu, Saeid Ansaryan

Methods for the analysis of cell secretions at the single-cell level only provide semiquantitative endpoint readouts. Here we describe a microwell array for the real-time spatiotemporal monitoring of extracellular secretions from hundreds of single cells i ...

NATURE PORTFOLIO2023

Plasmon-enhanced circular dichroism spectroscopy of chiral drug solutions

Hatice Altug

We investigate the potential of surface plasmon polaritons at noble metal interfaces for surface-enhanced chiroptical sensing of dilute chiral drug solutions with nl volume. The high quality factor of surface plasmon resonances in both Otto and Kretschmann ...

Aip Publishing2023

Metasurface-Enhanced Infrared Spectroscopy: An Abundance of Materials and Functionalities

Hatice Altug, Felix Ulrich Richter, Andreas Tittl, Aurélian Michel John-Herpin

Infrared spectroscopy provides unique information on the composition and dynamics of biochemical systems by resolving the characteristic absorption fingerprints of their constituent molecules. Based on this inherent chemical specificity and the capability ...

Wiley-V C H Verlag Gmbh2023

Rainbow dielectric metasurfaces for tunable resonant generation of high harmonics

Hatice Altug, Felix Ulrich Richter

We design high-Q metasurfaces with resonant wavelengths in mid-IR varying continuously along the sample. We demonstrate tunable rainbow generation of high harmonics as we vary the pump wavelength and the coordinate along the metasurface. ...

Optical Society of America2023

Dielectric Tetramer Nanoresonators Supporting Strong Superchiral Fields for Vibrational Circular Dichroism Spectroscopy

Hatice Altug, Felix Ulrich Richter, Yasaman Jahani, Rui Lu, Bang Hyun Lee, Ming-Lun Tseng, Longfang Ye

Chirality (C) is a fundamental property of objects, in terms of symmetry. It is extremely important to sense and distinguish chiral molecules in the fields of biochemistry, science, and medicine. Vibrational circular dichroism (VCD) spectroscopy, obtained ...

Amer Chemical Soc2023

Antenna-coupled infrared nanospectroscopy of intramolecular vibrational interaction

Hatice Altug, Aurélian Michel John-Herpin, Felipe Herrera

Many photonic and electronic molecular properties, as well as chemical and biochemical reactivities are controlled by fast intramolecular vibrational energy redistribution (IVR). This fundamental ultrafast process limits coherence time in applications from ...

National Academy of Sciences2023

Artificial intelligence-coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases

Hilal Lashuel, Hatice Altug, Deepthy Kavungal, Rajasekhar Kolla, Pedro José Santana Ribeiro Magalhães

Diagnosis of neurodegenerative disorders (NDDs) including Parkinson's disease and Alzheimer's disease is challenging owing to the lack of tools to detect preclinical biomarkers. The misfolding of proteins into oligomeric and fibrillar aggregates plays an i ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Molecular profiling of tumor-specific cytolytic CD4 T cells in human cancer

Hatice Altug, Xiaokang Li, Xuan Li, Yen-Cheng Liu

WILEY2022

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Artificial intelligence-coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases

Hilal Lashuel, Hatice Altug, Deepthy Kavungal, Rajasekhar Kolla, Pedro José Santana Ribeiro Magalhães

AMER ASSOC ADVANCEMENT SCIENCE2023