Publications de Alessia Perino

Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway

Johan Auwerx, Alessia Perino, Adrienne Joëlle Laurence Mottis, Jean-David Horacio Morel

Nori is a component of the traditional Japanese diet. The Japanese have a low prevalence of obesity and cardiovascular disease worldwide, and components of nori may have disease-preventive effects. Here, we focused on porphyran, which is abundant in nori t ...

2025

Bile acid 7α-dehydroxylating bacteria accelerate injury-induced mucosal healing in the colon

Kristina Schoonjans, Rizlan Bernier-Latmani, Alessia Perino, Hadrien Charles Edouard Demagny, Eduard Vico Oton, Colin Volet, Antoine Jalil

Host-microbiome communication is frequently perturbed in gut pathologies due to microbiome dysbiosis, leading to altered production of bacterial metabolites. Among these, 7 alpha-dehydroxylated bile acids are notably diminished in inflammatory bowel diseas ...

SPRINGERNATURE2025

Protecting liver health with microbial-derived succinylated bile acids

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny

The gut microbiome produces a plethora of metabolites that influence host metabolism. In a recent article published in Cell, Nie and colleagues reveal that 3-succinylated cholic acid, a microbe-derived bile acid, protects against metabolic dysfunction-asso ...

OXFORD UNIV PRESS2024

A microbial-derived succinylated bile acid to safeguard liver health

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny

In this issue of Cell, Nie and co-authors report that the microbe-derived bile acid (BA) 3-succinylated cholic acid protects against the progression of metabolic dysfunction-associated liver disease. Intriguingly, its protective mechanism does not involve ...

Cell Press2024

Wars1 downregulation in hepatocytes induces mitochondrial stress and disrupts metabolic homeostasis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Hadrien Charles Edouard Demagny, Antoine Jalil

Several laboratories, including ours, have employed the Slc25a47tm1c(EUCOMM)Hmgu mouse model to investigate the role of SLC25A47, a hepatocyte-specific mitochondrial carrier, in regulating hepatic metabolism and systemic physiology. In this study, we revea ...

2024

An antibiotic and a microorganism having bile acid 7α-dehydroxylation activity for treating non-infectious diseases

Kristina Schoonjans, Alessia Perino, Antoine Jalil

The present invention relates to one or more antibiotic(s) that disrupt(s) the microbial balance of the gut and a microorganism having bile acid 7α-dehydroxylation activity for use in the treatment of a non-infectious disease in a subject. ...

2024

The Bile Acid Receptor Tgr5 Regulates The Composition And Hematopoietic Support Capacity Of The Bone Marrow Microenvironment

Kristina Schoonjans, Alessia Perino, Antoine Jalil, Frédérica Schyrr, Alejandro Alonso Calleja

ELSEVIER SCIENCE INC2023

Role of TGR5 in fat-to-liver communication during NAFLD

Kristina Schoonjans, Alessia Perino

ELSEVIER2023

The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche

Dominique Pioletti, Kristina Schoonjans, Alessia Perino, Ulrike Kettenberger, Antoine Jalil, Frédérica Schyrr, Alejandro Alonso Calleja

Smw Supporting Association2023

Asparagine protects pericentral hepatocytes during acute liver injury

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Antoine Jalil, Ece Yildiz, Yu Sun, Nadia Bresciani

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in vivo ...

AMER SOC CLINICAL INVESTIGATION INC2023