Publications de Alex Mogilner | EPFL Graph Search

Actin-myosin viscoelastic flow in the keratocyte lamellipod

Maxime Fred Maurice Fournier, Alex Mogilner

The lamellipod, the locomotory region of migratory cells, is shaped by the balance of protrusion and contraction. The latter is the result of myosin-generated centripetal flow of the viscoelastic actin network. Recently, quantitative flow data was obtained ...

2009

A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays

Henning Paul-Julius Stahlberg, Li Tao, Alex Mogilner

Background: Mitosis depends upon the cooperative action of multiple microtubule (MT)-based motors. Among these, a kinesin-5, KLP61 F, and the kinesin-14, Ncd, are proposed to generate antagonistic-sliding forces that control the spacing of the spindle pole ...

Elsevier BV2006

Weak force stalls protrusion at the leading edge of the lamellipodium

Jean-Jacques Meister, Sophie Bohnet, Alex Mogilner

Protrusion, the first step of cell migration, is driven by actin polymerization coupled to adhesion at the cell's leading edge. Polymerization and adhesive forces have been estimated, but the net protrusion force has not been measured accurately. We arrest ...

Elsevier2005

Model of coupled transient changes of Rac, Rho, adhesions and stress fibers alignment in endothelial cells responding to shear stress

Jean-Jacques Meister, Alex Mogilner

Interactions of cell adhesions, Rho GTPases and actin in the endothelial cells' response to external forces are complex and not fully understood, but a qualitative understanding of the mechanosensory response begins to emerge. Here, we formulate a mathemat ...

Elsevier2004

Analysis of actin dynamics at the leading edge of crawling cells: implications for the shape of keratocyte lamellipodia

Jean-Jacques Meister, Alex Mogilner

Leading edge protrusion is one of the critical events in the cell motility cycle and it is believed to be driven by the assembly of the actin network. The concept of dendritic nucleation of actin filaments provides a basis for understanding the organizatio ...

Springer Verlag2003

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