Publications de Maria Anna Sofia Broggi

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients

Davide Demurtas, Melody Swartz, Romain Hamelin, Lambert Charles François Potin, Patricia Corthésy Henrioud, Natacha Anne-Sophie Bordry, Maria Anna Sofia Broggi, Léa Maillat, Alexandre Harari

Liquid biopsies allow monitoring of cancer progression and detection of relapse, but reliable biomarkers in melanoma are lacking. Because secreted factors preferentially drain to lymphatic vessels before dilution in the blood, we hypothesized that lymph sh ...

ROCKEFELLER UNIV PRESS2019

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

Jeffrey Alan Hubbell, Xavier Fredy René Quaglia-Thermes, Melody Swartz, Giacomo Olimpio Diaceri, Sachiko Hirosue, Laura Jeanbart, David Scott Wilson, Maria Anna Sofia Broggi, Michal Mateusz Raczy, Ruyi Wang

Fully effective vaccines for complex infections must elicit a diverse repertoire of antibodies (humoral immunity) and CD8+ T-cell responses (cellular immunity). Here, we present a synthetic glyco-adjuvant named p(Man-TLR7), which, when conjugated to antige ...

NATURE PUBLISHING GROUP2019

Lymphatic vessel density is associated with CD8(+) T cell infiltration and immunosuppressive factors in human melanoma

Melody Swartz, Olivier Michielin, Manuel Andreas Fankhauser, Timothy Murray, Natacha Anne-Sophie Bordry, Maria Anna Sofia Broggi, Esther Danenberg

Increased density of tumor-associated lymphatic vessels correlates with poor patient survival in melanoma and other cancers, yet lymphatic drainage is essential for initiating an immune response. Here we asked whether and how lymphatic vessel density (LVD) ...

TAYLOR & FRANCIS INC2018

Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma

Melody Swartz, Douglas Hanahan, Olivier Michielin, Krisztian Homicsko, Marcela Rincón-Restrepo, Christopher Claude Giuseppe Tremblay, Amanda Waite Lund, Laura Jeanbart, Lambert Charles François Potin, Manuel Andreas Fankhauser

In melanoma, vascular endothelial growth factor-C (VEGF-C) expression and consequent lymphangiogenesis correlate with metastasis and poor prognosis. VEGF-C also promotes tumor immunosuppression, suggesting that lymphangiogenesis inhibitors may be clinicall ...

Amer Assoc Advancement Science2017

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

Melody Swartz, Amanda Waite Lund, Manuel Andreas Fankhauser, Maria Anna Sofia Broggi

Lymphatic remodeling in tumor microenvironments correlates with progression and metastasis, and local lymphatic vessels play complex and poorly understood roles in tumor immunity. Tumor lymphangiogenesis is associated with increased immune suppression, yet ...

Amer Soc Clinical Investigation Inc2016