Publications de Adrian Pascal Nievergelt

A high-bandwidth voltage amplifier for driving piezoelectric actuators in high-speed atomic force microscopy

Georg Fantner, Adrian Pascal Nievergelt, Santiago Harald Andany, Mustafa Kangül

High-speed atomic force microscopy (HS-AFM) is a technique capable of revealing the dynamics of biomolecules and living organisms at the nanoscale with a remarkable temporal resolution. The phase delay in the feedback loop dictates the achievable speed of ...

AIP Publishing2023

Kinetic and structural roles for the surface in guiding SAS-6 self-assembly to direct centriole architecture

Pierre Gönczy, Georg Fantner, Georgios Hatzopoulos, Adrian Pascal Nievergelt, Niccolo Banterle, Santiago Harald Andany, Charlène Cécile Geneviève Brillard

Discovering mechanisms governing organelle assembly is a fundamental pursuit in biology. The centriole is an evolutionarily conserved organelle with a signature 9-fold symmetrical chiral arrangement of microtubules imparted onto the cilium it templates. Th ...

Nature Portfolio2021

Time-Resolved Scanning Ion Conductance Microscopy for Three-Dimensional Tracking of Nanoscale Cell Surface Dynamics

Aleksandra Radenovic, Georg Fantner, Daniel Constam, Alexandre Louis André Persat, Barney Frederick Drake, Adrian Pascal Nievergelt, Vytautas Navikas, Samuel Mendes Leitão, Xavier Jean-Yves Pierrat, Charlène Cécile Geneviève Brillard

Nanocharacterization plays a vital role in understanding the complex nanoscale organization of cells and organelles. Understanding cellular function requires high-resolution information about how the cellular structures evolve over time. A number of techni ...

AMER CHEMICAL SOC2021

Overlapping and essential roles for molecular and mechanical mechanisms in mycobacterial cell division

Georg Fantner, John McKinney, Adrian Pascal Nievergelt, Pascal Damian Odermatt, Haig Alexander Eskandarian, Mélanie Thérèse Marie Hannebelle

Mechanisms to control cell division are essential for cell proliferation and survival. Bacterial cell growth and division require the coordinated activity of peptidoglycan synthases and hydrolytic enzymes to maintain mechanical integrity of the cell wall. ...

2020

Large‐Range HS‐AFM Imaging of DNA Self‐Assembly through In Situ Data‐Driven Control

Alireza Karimi, Georg Fantner, Maartje Martina Cornelia Bastings, Adrian Pascal Nievergelt, Christoph Manuel Kammer, Eva Eugene Kurisinkal, Charlène Cécile Geneviève Brillard

Understanding hierarchical self-assembly of biological structures requires real time measurement of the self-assembly process over a broad range of length- and timescales. The success of high-speed atomic force microscopy (HS-AFM) in imaging small scale mo ...

2019

Time-Lapse Atomic Force Microscopy Reveals New End Take Off (Neto) Dynamics in Mycobacteria

Georg Fantner, John McKinney, Adrian Pascal Nievergelt, Haig Alexander Eskandarian, Chiara Toniolo, Mélanie Thérèse Marie Hannebelle, Joëlle Xiao Yuan Ven

CELL PRESS2019

Detecting topological variations of DNA at single-molecule level

Aleksandra Radenovic, Georg Fantner, Adrian Pascal Nievergelt, Ke Liu

In addition to their use in DNA sequencing, ultrathin nanopore membranes have potential applications in detecting topological variations in deoxyribonucleic acid (DNA). This is due to the fact that when topologically edited DNA molecules, driven by electro ...

Nature Research2019

Single-molecule kinetics of pore assembly by the membrane attack complex

Georg Fantner, Adrian Pascal Nievergelt

The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. The MAC is formed by sequential assembly of soluble complement proteins C5b, C6, C7, C8 and C9, but little is known about th ...

Springer2019

Advances in High-Speed Atomic Force Microscopy

Adrian Pascal Nievergelt

High-speed atomic force microscopy (HS-AFM) is a scanning probe technique capable of recording processes at the nanometre scale in real time. By sequentially increasing the speed of individual microscope components, images of surfaces can be recorded at up ...

EPFL2018

An analog high-speed single-cycle lock-in amplifier for next generation AFM experiments

Georg Fantner, Jens Anders, Adrian Pascal Nievergelt

In this paper, we present a new architecture for analog amplitude demodulation in high-speed atomic force microscopy (AFM) applications. It features single-cycle capabilities and the possibility to work with elevated cantilever resonance frequencies up to ...

IEEE2018