Publications de Mark Andrew Anderson

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Léonie Asboth, Mark Andrew Anderson, Katia Galan, Robin Jonathan Demesmaeker, Nicholas David James, Matthieu Pierre Gautier, Nicolas Hankov

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

Neurotrauma treatment

Grégoire Courtine, Bernard Schneider, Jordan Squair, Mark Andrew Anderson

The invention provides pharmaceutical compositions, combinations and vectors, such as expression vectors, as well as use thereof in a method for central nervous system repair after neurotrauma, such as spinal cord injury (SCI) or stroke and in a method for ...

2024

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Grégoire Courtine, Bernard Schneider, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Mark Andrew Anderson, Katia Galan, Nicholas David James, Matthieu Pierre Gautier, Laetitia Danielle Philippine Baud

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulatio ...

American Association for the Advancement of Science2023

Natural and targeted circuit reorganization after spinal cord injury

Grégoire Courtine, Quentin Barraud, Jocelyne Bloch, Matthieu Pierre Gautier, Claudia Kathe, Jordan Squair, Mark Andrew Anderson, Thomas Haynes Hutson

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases. ...

NATURE PORTFOLIO2022

Engineering spinal cord repair

Grégoire Courtine, Jordan Squair, Matthieu Pierre Gautier, Mark Andrew Anderson, Michael V. Sofroniew

Neurological damage caused by spinal cord injury in humans has been observed for over three thousand years and impacts the lives of several hundred thousand people worldwide. Despite this prevalence and its associated consequences, there is no treatment to ...

CURRENT BIOLOGY LTD2021

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Quentin Barraud, Jordan Squair, Giuseppe Schiavone, Ileana Ozana Jelescu, Mark Andrew Anderson, Robin Jonathan Demesmaeker

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Targeting Central Nervous System Regeneration with Cell Type Specificity

Mark Andrew Anderson

2021

Cell type prioritization in single-cell data

Grégoire Courtine, Gioele La Manno, Quentin Barraud, Jordan Squair, Mark Andrew Anderson, Matthieu Pierre Gautier, Claudia Kathe, Thomas Haynes Hutson, Marco Milano, Michael Alexander Skinnider

The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis. ...

NATURE PUBLISHING GROUP2021

Confronting false discoveries in single-cell differential expression

Grégoire Courtine, Gioele La Manno, Quentin Barraud, Jordan Squair, Mark Andrew Anderson, Nicholas David James, Matthieu Pierre Gautier, Thomas Haynes Hutson, Rémi Bernard René Hudelle, Claudia Kathe

Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show that many commonly used methods are biased and can produce false discoveries. ...

Nature Portfolio2021

Required growth facilitators propel axon regeneration across complete spinal cord injury

Grégoire Courtine, Mark Andrew Anderson, Nicholas David James, Cheng Wang, Sabry Leonardo Barlatey, Michael V. Sofroniew, Zhigang He

Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury1,2,3, but efficient reversal of this regrowth failure ...

2018