Publications de Vera Monica Lemos Da Silva

Evidence for a neuromuscular circuit involving hypothalamic interleukin-6 in the control of skeletal muscle metabolism

Vera Monica Lemos Da Silva, Ludger Jan Elzuë Goeminne, Barbara Moreira Crisol, Eduardo Rochete Ropelle

Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control. Here, we demonstrated that IL6 activates the ERK1/2 pathway in the ventromedial hypothalamus (VMH), stimulating AMPK/ACC signaling and fatty acid oxidation in mouse skeletal muscle. Bioinfo ...

2022

The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Vera Monica Lemos Da Silva, Hadrien Charles Edouard Demagny, Hao Li, Yu Sun, Nadia Bresciani

Background & Aims: Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological r ...

ELSEVIER2022

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Johan Auwerx, Kristina Schoonjans, Bernard Schneider, Graham Knott, Davide D'Amico, Vera Monica Lemos Da Silva, Mario Romani, Vincenzo Sorrentino, Adrienne Joëlle Laurence Mottis, Hao Li

Little information is available about how post-transcriptional mechanisms regulate the aging process. Here, we show that the RNA-binding protein Pumilio2 (PUM2), which is a translation repressor, is induced upon aging and acts as a negative regulator of li ...

CELL PRESS2019

A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model

Kristina Schoonjans, Vera Monica Lemos Da Silva, Evan Graehl Williams, Pan Xu, Amir Banaei Esfahani, Chen Li, Ruedi Aebersold

To-date, most proteomic studies aimed at discovering tissue-based cancer biomarkers have compared the quantity of selected proteins between case and control groups. However, proteins generally function in association with other proteins to form modules loc ...

Nature Research2019

TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

Kristina Schoonjans, Alessia Perino, Vera Monica Lemos Da Silva, Mitsunori Nomura, Thijs Pols, Laura Alejandra Velazquez Villegas, Marika Olga Zietak

Nature Research2018

The NAD(+)-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

Vera Monica Lemos Da Silva

Insulin resistance is a major predictor of the development of metabolic disorders. Sirtuins (SIRTs) have emerged as potential targets that can be manipulated to counteract age-related diseases, including type 2 diabetes. SIRT2 has been recently shown to ex ...

Oxford University Press2017

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Dongryeol Ryu, Vera Monica Lemos Da Silva, Elena Katsyuba, Jun Yong Kim, Hongbo Zhang, Pooja Jha, Keir Joe Menzies

Background & Aims: To date, no pharmacological therapy has been approved for non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the therapeutic potential of poly ADP-ribose polymerase (PARP) inhibitors in mouse models o ...

Elsevier Science Bv2017

Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

Kristina Schoonjans, Pan Xu, Vera Monica Lemos Da Silva, Hadrien Charles Edouard Demagny, Dongryeol Ryu, Xu Wang, Matthias Alexander Sokrates Stein, Maaike Hélène Oosterveer

Hepatic steatosis is caused by metabolic imbalances that could be explained in part by an increase in de novo lipogenesis that results from increased sterol element binding protein 1 (SREBP-1) activity. The nuclear receptor liver receptor homolog 1 (LRH-1) ...

Amer Soc Clinical Investigation Inc2017

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

Kristina Schoonjans, Alessia Perino, Dongryeol Ryu, Vera Monica Lemos Da Silva, Xu Wang, Chikage Mataki, Pan Xu, Keir Joe Menzies, Matthias Alexander Sokrates Stein, Maaike Hélène Oosterveer

Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) driv ...

Cell Press2014