Publications de Andrea Brigitta Alber

Endogenous fluctuations of OCT 4 and SOX 2 bias pluripotent cell fate decisions

David Michael Suter, Cédric Deluz, Torgil Elias Friman, Andrea Brigitta Alber, Subashika Govindan, Daniel Strebinger

SOX2 and OCT4 are pioneer transcription factors playing a key role in embryonic stem (ES) cell self‐renewal and differentiation. How temporal fluctuations in their expression levels bias lineage commitment is unknown. Here, we generated knock‐in reporter f ...

2019

Dynamics of protein synthesis and degradation through the cell cycle

David Michael Suter, Andrea Brigitta Alber

Protein expression levels depend on the balance between their synthesis and degradation rates. Even quiescent (G(0)) cells display a continuous turnover of proteins, despite protein levels remaining largely constant over time. In cycling cells, global prot ...

TAYLOR & FRANCIS INC2019

Mitotic chromosome binding predicts transcription factor properties in interphase

Cédric Deluz, David Michael Suter, Torgil Elias Friman, Andrea Brigitta Alber, Mahé Cécile Raccaud

Mammalian transcription factors (TFs) differ broadly in their nuclear mobility and sequence-specific/non-specific DNA binding. How these properties affect their ability to occupy specific genomic sites and modify the epigenetic landscape is unclear. The as ...

Nature Research2019

Single-Cell Quantification of Protein Degradation Rates by Time-Lapse Fluorescence Microscopy in Adherent Cell Culture

David Michael Suter, Andrea Brigitta Alber

2018

Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions

Cédric Deluz, David Michael Suter, Subashika Govindan, Daniel Strebinger, Torgil Elias Friman, Andrea Brigitta Alber

MARY ANN LIEBERT, INC2018

Mitotic chromosome association predicts genome-wide transcription factor occupancy and impact on local chromatin accessibility

Cédric Deluz, David Michael Suter, Mahé Cécile Raccaud, Torgil Elias Friman, Andrea Brigitta Alber

MARY ANN LIEBERT, INC2018

Single Live Cell Monitoring of Protein Turnover Reveals Intercellular Variability and Cell-Cycle Dependence of Degradation Rates

Felix Naef, David Michael Suter, Andrea Brigitta Alber, Eric Paquet, Martina Biserni

Cells need to reliably control their proteome composition to maintain homeostasis and regulate growth. How protein synthesis and degradation interplay to control protein expression levels remains unclear. Here, we combined a tandem fluorescent timer and pu ...

CELL PRESS2018

Single live cell monitoring of protein turnover reveals intercellular variability and cell cycle dependence of degradation rates

Andrea Brigitta Alber

Cells need to be able to precisely control their proteome composition in order to maintain homeostasis. This is of particular relevance in fast dividing cells, such as embryonic stem cells, since their global protein levels need to be doubled at each divis ...

EPFL2018