Publications de Peiling Luan | EPFL Graph Search

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

Johan Auwerx, Davide D'Amico, Tanes Imamura de Lima, Qi Wang, Sébastien Robert Victor Herzig, Maroun Bou Sleiman, Martin Rainer Wohlwend, Peiling Luan, Pirkka-Pekka Untamo Laurila, Barbara Moreira Crisol

Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse skeletal muscle upon aging and that both genetic a ...

2022

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

Johan Auwerx, Tanes Imamura de Lima, Martin Rainer Wohlwend, Peiling Luan, Pirkka-Pekka Untamo Laurila, Ludger Jan Elzuë Goeminne

Duchenne muscular dystrophy (DMD), the most common muscular dystrophy, is a severe muscle disorder, causing muscle weakness, loss of independence, and premature death. Here, we establish the link between sphingolipids and muscular dystrophy. Transcripts of ...

2022

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

Johan Auwerx, Pénélope Andreux, Davide D'Amico, Hao Li, Tanes Imamura de Lima, Martin Rainer Wohlwend, Peiling Luan, Pirkka-Pekka Untamo Laurila

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite advances in genetic and pharmacological disease-modifying treatments, its management remains a major challenge. Mitochondrial dysfunction contributes to DMD, yet the mecha ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Metabolic rescue of muscle and muscle stem cells in muscle disease

Peiling Luan

Duchenne muscular dystrophy (DMD), caused by the mutation of dystrophin gene, is an X-linked disorder that affects 1 in 3500 males, leading to progressive muscle degeneration and eventually resulting in premature death. Increasing evidence indicates that D ...

EPFL2020

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

Johan Auwerx, Kristina Schoonjans, Stephan Morgenthaler, Hao Li, Maroun Bou Sleiman, Xu Wang, Vincenzo Sorrentino, Hongbo Zhang, Peiling Luan, Tao Lin

2018

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Johan Auwerx, Kristina Schoonjans, Matthias Lütolf, Davide D'Amico, Dongryeol Ryu, Xu Wang, Hongbo Zhang, Peiling Luan, Keir Joe Menzies, Karim Laurent Gariani

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD(+)) and its imp ...

American Association for the Advancement of Science2016