Publications de Ninad Dilip Agashe

Tubulin engineering by semi-synthesis reveals that polyglutamylation directs detyrosination

Pierre Gönczy, Beat Fierz, Luc Reymond, Georgios Hatzopoulos, Cédric Pourroy, Po-Han Chang, Nora Guidotti, Ninad Dilip Agashe, Timothy Matthias Reichart, Eduard Hubert Theodoor Marius Ebberink

Microtubules, a critical component of the cytoskeleton, carry post-translational modifications (PTMs) that are important for the regulation of key cellular processes. Long-lived microtubules, in neurons particularly, exhibit both detyrosination of a-tubuli ...

NATURE PORTFOLIO2023

Protein Engineering Tools to Explore the Function of Protein Post-Translational Modifications for Chromatin and Microtubule Cytoskeletal Biology

Ninad Dilip Agashe

Protein post-translational modifications (PTMs) play a crucial role in expanding the protein diversity and are one of the major mechanisms through which cells respond to ever changing environmental cues. The function of two of the most important cellular c ...

EPFL2019

Pancreatic beta cell based optical biosensor and system for continuous glucose monitoring

Catherine Dehollain, Umberto De Marchi, Bakul Jitendra Vinchhi, Ninad Dilip Agashe, Nicolas Bouche, Christophe Boss

A bio-electronics system that measures cytosolic [Ca2+] in vitro in the INS-1E pancreatic beta-cells using a 430 nm excitation light with the excitation wavelength of the probe being at 435 nm was successfully implemented and tested. We transfected the INS ...

IEEE2019

Traceless Synthesis of Asymmetrically Modified Bivalent Nucleosomes

Beat Fierz, Carolin Christine Lechner, Ninad Dilip Agashe

Nucleosomes carry extensive post-translational modifications (PTMs), which results in complex modification patterns that are involved in epigenetic signaling. Although two copies of each histone coexist in a nucleosome, they may not carry the same PTMs and ...

Wiley-VCH Verlag GmbH2016