Hao Li

Cette personne n’est plus à l’EPFL

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Publications associées (26)

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

Johan Auwerx, Hao Li, Daniel Garcia

Rapid alterations in cellular metabolism allow tissues to maintain homeostasis during changes in energy availability. The central metabolic regulator acetyl-CoA carboxylase 2 (ACC2) is robustly phosphorylated during cellular energy stress by AMP-activated ...

Cell Press2020

Cross-species functional modules link proteostasis to human normal aging

Johan Auwerx, Hao Li, Vincenzo Sorrentino, Andrea Komljenovic

The evolutionarily conserved nature of the few well-known anti-aging interventions that affect lifespan, such as caloric restriction, suggests that aging-related research in model organisms is directly relevant to human aging. Since human lifespan is a com ...

2019

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Johan Auwerx, Kristina Schoonjans, Bernard Schneider, Graham Knott, Davide D'Amico, Vera Monica Lemos Da Silva, Mario Romani, Vincenzo Sorrentino, Adrienne Joëlle Laurence Mottis, Hao Li

Little information is available about how post-transcriptional mechanisms regulate the aging process. Here, we show that the RNA-binding protein Pumilio2 (PUM2), which is a translation repressor, is induced upon aging and acts as a negative regulator of li ...

CELL PRESS2019

Systems genetics approaches to probe gene function

Hao Li

Genes are the functional units of heredity. However, the functions of many genes remain unknown, which impedes the understanding of the underlying mechanism of complex traits and diseases. Systems genetics approaches try to understand the complexity underl ...

EPFL2019

Identifying gene function and module connections by the integration of multispecies expression compendia

Johan Auwerx, Kristina Schoonjans, Stephan Morgenthaler, Fabrice David, Hao Li, Maroun Bou Sleiman, Elena Katsyuba, Wen Gao, Daria Rukina, Qingyao Huang

The functions of many eukaryotic genes are still poorly understood. Here, we developed and validated a new method, termed GeneBridge, which is based on two linked approaches to impute gene function and bridge genes with biological processes. First, Gene-Mo ...

Cold Spring Harbor Laboratory2019

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

Johan Auwerx, Hao Li

2018

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

Johan Auwerx, Kristina Schoonjans, Stephan Morgenthaler, Hao Li, Maroun Bou Sleiman, Xu Wang, Vincenzo Sorrentino, Hongbo Zhang, Peiling Luan, Tao Lin

2018

Modern techniques and applications for real-time non-rigid registration

Mark Pauly, Sofien Bouaziz, Hao Li, Andrea Tagliasacchi

Registration algorithms are an essential component of many computer graphics and computer vision systems. With recent technological advances in RGBD sensors (color plus depth), an active area of research is in techniques combining color, geometry, and lear ...

2016

Wireless Neurosensor for Full-Spectrum Electrophysiology Recordings during Free Behavior

Grégoire Courtine, Hao Li, David Allenson Borton, Yao Lu, Jean François Pierre Laurens

Brain recordings in large animal models and humans typically rely on a tethered connection, which has restricted the spectrum of accessible experimental and clinical applications. To overcome this limitation, we have engineered a compact, lightweight, high ...

Cell Press2014

Factored Facade Acquisition using Symmetric Line Arrangements

Mark Pauly, Duygu Ceylan, Hao Li

We introduce a novel framework for image-based 3D reconstruction of urban buildings based on symmetry priors. Starting from image-level edges, we generate a sparse and approximate set of consistent 3D lines. These lines are then used to simultaneously dete ...

2012

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