Publications de Pooja Jha | EPFL Graph Search

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

Johan Auwerx, Sandra Rodriguez Lopez, Maroun Bou Sleiman, Pooja Jha, Martin Rainer Wohlwend, Pirkka-Pekka Untamo Laurila, Ludger Jan Elzuë Goeminne

Benegiamo et al. identify genetic variants of the mitochondrial supercomplex assembly factor COX7A2L in the skeletal muscle of mice and humans that promote cardiorespiratory fitness. ...

NATURE PORTFOLIO2022

The mouse metallomic landscape of aging and metabolism

Johan Auwerx, Richardus Houtkooper, Evan Graehl Williams, Pooja Jha, Ludger Jan Elzuë Goeminne, Jean-David Horacio Morel

The metallome is crucial for normal cell functioning but remains largely overlooked in mammals. Here the authors analyze the metallome and copper and zinc isotope compositions in aging mice and show networks of interactions that are organ-specific, age-dep ...

Nature Research2022

Gene-by-environment modulation of lifespan and weight gain in the murine BXD family

Johan Auwerx, Maroun Bou Sleiman, Evan Graehl Williams, Pooja Jha

How lifespan and body weight vary as a function of diet and genetic differences is not well understood. Here we quantify the impact of differences in diet on lifespan in a genetically diverse family of female mice, split into matched isogenic cohorts fed a ...

NATURE PORTFOLIO2021

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Johan Auwerx, Richardus Houtkooper, Maroun Bou Sleiman, Xu Wang, Pooja Jha

Many genes and pathways have been linked to aging, yet our understanding of underlying molecular mechanisms is still lacking. Here, we measure changes in the transcriptome, histone modifications, and DNA methylome in three metabolic tissues of adult and ag ...

2020

Plasma and liver lipid species as biomarkers of fatty liver

Johan Auwerx, Pooja Jha

The invention relates to plasma or liver lipid species selected from the triacylglycerol (TAG) and cardiolipin (CL) lipid classes measured by LC-MS/MS and use thereof as diagnostic and prognostic biomarkers of fatty liver, as well as to monitor the efficac ...

2018

ERR gamma Preserves Brown Fat Innate Thermogenic Activity

Johan Auwerx, Pooja Jha

2018

Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes

Johan Auwerx, Maroun Bou Sleiman, Evan Graehl Williams, Karim Laurent Gariani, Pooja Jha, Pedro Moral Quiros

2018

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes

Johan Auwerx, Pooja Jha

2018

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species

Johan Auwerx, Maroun Bou Sleiman, Evan Graehl Williams, Karim Laurent Gariani, Pooja Jha, Léo Aurélio Diserens, Pedro Moral Quiros

2018

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population

Johan Auwerx, Jun Yong Kim, Dongryeol Ryu, Evan Graehl Williams, Pooja Jha, Jiayi Lan, Ruedi Aebersold, Moaraj Hasan

We have used SWATH mass spectrometry to quantify 3648 proteins across 76 proteomes collected from genetically diverse BXD mouse strains in two fractions (mitochondria and total cell) from five tissues: liver, quadriceps, heart, brain, and brown adipose (BA ...

AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2018