Pooja Jha

Cette personne n’est plus à l’EPFL

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Publications associées (14)

Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle

Johan Auwerx, Carlos Canto Alvarez, Xu Wang, Pooja Jha, Chiara Greggio

Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiova ...

Cell Press2017

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Dongryeol Ryu, Vera Monica Lemos Da Silva, Elena Katsyuba, Jun Yong Kim, Hongbo Zhang, Pooja Jha, Keir Joe Menzies

Background & Aims: To date, no pharmacological therapy has been approved for non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the therapeutic potential of poly ADP-ribose polymerase (PARP) inhibitors in mouse models o ...

Elsevier Science Bv2017

Systems proteomics of liver mitochondria function

Johan Auwerx, Evan Graehl Williams, Pooja Jha, Tiffany Amariuta, Ruedi Aebersold, Sébastien Dubuis

Recent improvements in quantitative proteomics approaches, including Sequential Window Acquisition of all Theoretical Mass Spectra (SWATH-MS), permit reproducible large-scale protein measurements across diverse cohorts. Together with genomics, transcriptom ...

American Association for the Advancement of Science2016

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Johan Auwerx, Maria del Carmen Sandi Perez, Patrick Aebischer, Dongryeol Ryu, Laurent Mouchiroud, Elena Katsyuba, Pénélope Andreux, Norman Lionel Moullan, Evan Graehl Williams, Pooja Jha

The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as well as in nuts and berries. We ...

2016

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