Personne
Annina Stuber
Cette personne n’est plus à l’EPFL
Publications associées (6)
Aptamer Renaissance for Neurochemical Biosensing
Unraveling the complexities of brain function, which is crucial for advancing human health, remains a grand challenge. This endeavor demands precise monitoring of small molecules such as neurotransmitters, the chemical messengers in the brain. In this Pers ...
2024Solid-State Nanopores for Biomolecular Analysis and Detection
Advances in nanopore technology and data processing have rendered DNA sequencing highly accessible, unlocking a new realm of biotechnological opportunities. Commercially available nanopores for DNA sequencing are of biological origin and have certain disad ...
Springer Link2024Interfacing aptamer-modified nanopipettes with neuronal media and ex vivo brain tissue
Nako Nakatsuka, Anna Burdina, Annina Stuber
Aptamer-functionalized biosensors exhibit high selectivity for monitoring neurotransmitters in complex environments. We translated nanoscale aptamer-modified nanopipette sensors to detect endogenous dopamine release in vitro and ex vivo. These sensors empl ...
2023Theoretical analysis of divalent cation effects on aptamer recognition of neurotransmitter targets
Nako Nakatsuka, Dmitry Momotenko, Annina Stuber
Aptamer-based sensing of small molecules such as dopamine and serotonin in the brain, requires characterization of the specific aptamer sequences in solutions mimicking the in vivo environment with physiological ionic concentrations. In particular, divalen ...
2023Aptamer Conformational Dynamics Modulate Neurotransmitter Sensing in Nanopores
Nako Nakatsuka, Dmitry Momotenko, Annina Stuber
Aptamers that undergo conformational changes upon small-molecule recognition have been shown to gate the ionic flux through nanopores by rearranging the charge density within the aptamer-occluded orifice. However, mechanistic insight into such systems wher ...
2023Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure
Yi Zhang, Annina Stuber, Ashish Gupta
BACKGROUND: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to contractile dysfunction, but their role, if any, in HF-related pathologic remodeling is much less established. CK (creatine kinase), the primary muscle ene ...
LIPPINCOTT WILLIAMS & WILKINS2022