Publications de Muhammet Fatih Gülen

cGAS-STING drives ageing-related inflammation and neurodegeneration

Andrea Ablasser, Bastien Mangeat, Muhammet Fatih Gülen, Chong Liu, Vivek Vijay Thacker, Natasha Ella Samson, Sélène-Véronique Glück

Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated impairment and disease(1). Multiple factors can contribute to ageing-associated inflammation(2); however, the molecular pathways that transduce aberrant inflammatory ...

2023

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

Andrea Ablasser, Muhammet Fatih Gülen, Théo Nass, Vivek Vijay Thacker, Martin Schaller, Kunal Sharma

COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications1,2. Type I interferons (IFNs) have an essential role in the pathogenesis of COVID-19 (refs 3–5). Although rapid induction of type I ...

2022

m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner

Andrea Ablasser, Muhammet Fatih Gülen

Nucleic acid sensing through pattern recognition receptors is critical for immune recognition of microbial infections. Microbial DNA is frequently methylated at the N-6 position of adenines (m6A), a modification that is rare in mammalian host DNA. We show ...

ROYAL SOC2021

Targeting STING with covalent small-molecule inhibitors

Françoise Gisou van der Goot Grunberg, Gerardo Turcatti, Laurence Gouzi Abrami, Andrea Ablasser, Luc Reymond, Muhammet Fatih Gülen, Alexiane Clara Decout, Simone Margret Haag, Michael Christian Heymann

2018

Signalling strength determines proapoptotic functions of STING

Freddy Radtke, Ute Koch, Andrea Ablasser, Muhammet Fatih Gülen

Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS-STING signalling pathway, which initiates a gene expression programme linked to ce ...

Springer Nature2017

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Andrea Ablasser, Muhammet Fatih Gülen, Baptiste Claude André Guey, Sélène-Véronique Glück, Niklas Arndt Schmacke

2017

The role of cGAS in innate immunity and beyond

Andrea Ablasser, Muhammet Fatih Gülen

The sensing of foreign DNA is crucial for host defense against several pathogens. In the cytosol the enzyme cyclic GMP-AMP synthase (cGAS) is critical for the recognition of pathogen-derived DNA and provides key signals that initiate immune responses. Beyo ...

2016

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

Stewart Cole, Andrea Ablasser, Claudia Sala, Muhammet Fatih Gülen, Sonia Garcia Perin, Ye Lou, Jan Lars Rybniker

Cytosolic detection of microbial products is essential for the initiation of an innate immune response against intracellular pathogens such as Mycobacterium tuberculosis (Mtb). During Mtb infection of macrophages, activation of cytosolic surveillance pathw ...

Cell Press2015

Inside Job: Viruses Transfer cGAMP between Cells

Andrea Ablasser, Muhammet Fatih Gülen

The DNA sensor, cyclic GMP-AMP synthase (cGAS), is essential for the detection of viral infection. In a recent issue of Science, two studies, Bridgeman et al. (2015) and Gentili et al. (2015), report a novel mechanism for propagating an antiviral signal be ...

Cell Press2015