Bruno Emanuel Ferreira De Sousa Correia

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Publications associées (179)

Dual ON/OFF-switch chimeric antigen receptor controlled by two clinically approved drugs

Bruno Emanuel Ferreira De Sousa Correia, Sandrine Madeleine Suzanne Georgeon, Leo Scheller, Sailan Shui

The ability to remotely control the activity of chimeric antigen receptors (CARs) with small molecules can improve the safety and efficacy of gene-modified T cells. Split ON- or OFF-switch CARs involve the dissociation of tumor–antigen binding from T cell ...

National Academy of Sciences2024

Epitope-focused immunogens targeting the hepatitis C virus glycoproteins induce broadly neutralizing antibodies

Bruno Emanuel Ferreira De Sousa Correia, Andreas Scheck, Stéphane Rosset, Sabrina Susan Vollers

Hepatitis C virus (HCV) infection causes similar to 290,000 annual human deaths despite the highly effective antiviral treatment available. Several viral immune evasion mechanisms have hampered the development of an effective vaccine against HCV, among the ...

AMER ASSOC ADVANCEMENT SCIENCE2024

The physiological landscape and specificity of antibody repertoires are consolidated by multiple immunizations

Bruno Emanuel Ferreira De Sousa Correia, Fabian Sesterhenn

Diverse antibody repertoires spanning multiple lymphoid organs (i.e., bone marrow, spleen, lymph nodes) form the foundation of protective humoral immunity. Changes in their composition across lymphoid organs are a consequence of B-cell selection and migrat ...

2024

Computational design of soluble and functional membrane protein analogues

Bruno Emanuel Ferreira De Sousa Correia, Sandrine Madeleine Suzanne Georgeon, Casper Alexander Goverde, Martin Pacesa, Stéphane Rosset

De novo design of complex protein folds using solely computational means remains a substantial challenge1. Here we use a robust deep learning pipeline to design complex folds and soluble analogues of integral membrane proteins. Unique membrane topologies, ...

2024

Structure-based drug design with equivariant diffusion models

Bruno Emanuel Ferreira De Sousa Correia, Arne Schneuing, Ilia Igashov

Structure-based drug design (SBDD) aims to design small-molecule ligands that bind with high affinity and specificity to pre-determined protein targets. Generative SBDD methods leverage structural data of drugs with their protein targets to propose new dru ...

SPRINGERNATURE2024

FSscore: A Personalized Machine Learning-Based Synthetic Feasibility Score

Bruno Emanuel Ferreira De Sousa Correia, Philippe Schwaller

Determining whether a molecule can be synthesized is crucial in chemistry and drug discovery, as it guides experimental prioritization and molecule ranking in de novo design tasks. Existing scoring approaches to assess synthetic feasibility struggle to ext ...

2024

Structures of the Foamy virus fusion protein reveal an unexpected link with the F protein of paramyxo- and pneumoviruses

Bruno Emanuel Ferreira De Sousa Correia, Casper Alexander Goverde

Foamy viruses (FVs) constitute a subfamily of retroviruses. Their envelope (Env) glycoprotein drives the merger of viral and cellular membranes during entry into cells. The only available structures of retroviral Envs are those from human and simian immuno ...

2024

An evolved artificial radical cyclase enables the construction of bicyclic terpenoid scaffolds via an H-atom transfer pathway

Bruno Emanuel Ferreira De Sousa Correia

While natural terpenoid cyclases generate complex terpenoid structures via cationic mechanisms, alternative radical cyclization pathways are underexplored. The metal-catalysed H-atom transfer reaction (M-HAT) offers an attractive means for hydrofunctionali ...

2024

Opportunities and challenges in design and optimization of protein function

Bruno Emanuel Ferreira De Sousa Correia, Casper Alexander Goverde

The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely structure-based design methods limited their application, but recent strategies that combine structure-based and sequence-based calcu ...

Nature Portfolio2024

A Synthetic Multivalent Lipopeptide Derived from Pam3CSK4 with Irreversible Influenza Inhibition and Immuno-Stimulating Effects

Francesco Stellacci, Li Tang, Bruno Emanuel Ferreira De Sousa Correia, Quy Ong Khac, Francesca Olgiati, Pablo Gainza Cirauqui, Lixia Wei, Armand Kurum, Yong Zhu

The activation of the host adaptive immune system is crucial for eliminating viruses. However, influenza infection often suppresses the innate immune response that precedes adaptive immunity, and the adaptive immune responses are typically delayed. Dendrit ...

Wiley-V C H Verlag Gmbh2024

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An evolved artificial radical cyclase enables the construction of bicyclic terpenoid scaffolds via an H-atom transfer pathway

Bruno Emanuel Ferreira De Sousa Correia

2024

Structure-based drug design with equivariant diffusion models

Bruno Emanuel Ferreira De Sousa Correia, Arne Schneuing, Ilia Igashov

SPRINGERNATURE2024

A Synthetic Multivalent Lipopeptide Derived from Pam3CSK4 with Irreversible Influenza Inhibition and Immuno-Stimulating Effects

Francesco Stellacci, Li Tang, Bruno Emanuel Ferreira De Sousa Correia, Quy Ong Khac, Francesca Olgiati, Pablo Gainza Cirauqui, Lixia Wei, Armand Kurum, Yong Zhu

Wiley-V C H Verlag Gmbh2024