Publications de Omid Mashinchian

In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

Patrick Descombes, Jérome Feige, Sylviane Métairon, Omid Mashinchian, Filippo De Franceschi, Nicolas Bouche, Christophe Boss

Sustained exposure to a young systemic environment rejuvenates aged organisms and promotes cellular function. However, due to the intrinsic complexity of tissues it remains challenging to pinpoint niche-independent effects of circulating factors on specifi ...

2022

An engineered multicellular stem cell niche for the 3D derivation of human myogenic progenitors from iPSCs

Matthias Lütolf, Omid Mashinchian, Jérome Feige

Fate decisions in the embryo are controlled by a plethora of microenvironmental interactions in a three-dimensional niche. To investigate whether aspects of this microenvironmental complexity can be engineered to direct myogenic human-induced pluripotent s ...

WILEY2022

Neural priming of adipose-derived stem cells by cell-imprinted substrates*

Philippe Renaud, Omid Mashinchian

Cell-imprinting technology is a novel method for directing stem cell fate using substrates molded from target cells. Here, we fabricated and studied cell-imprinted substrates for neural priming in human adipose-derived stem cells in the absence of chemical ...

IOP PUBLISHING LTD2021

Nutritional Control of Intestinal Stem Cells in Homeostasis and Tumorigenesis

Omid Mashinchian

Food and nutrition have a profound impact on organismal health and diseases, and tissue-specific adult stem cells play a crucial role in coordinating tissue maintenance by responding to dietary cues. Emerging evidence indicates that adult intestinal stem c ...

ELSEVIER SCIENCE LONDON2021

Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors

Patrick Descombes, Omid Mashinchian, Guillaume Jacot, Sylviane Métairon, Sonia Karaz, Laura Lukjanenko, Federico Sizzano, Sara Ancel

Research on age-related regenerative failure of skeletal muscle has extensively focused on the phenotypes of muscle stem cells (MuSCs). In contrast, the impact of aging on regulatory cells in the MuSC niche remains largely unexplored. Here, we demonstrate ...

CELL PRESS2019

Bioengineering the Human Muscle Stem-Cell Niche for Therapeutic Applications

Omid Mashinchian

In spite of decades of research, no feasible method for obtaining sufficient numbers of uncommitted muscle stem cells (MuSCs) for therapy of degenerative muscle diseases exists. One of the most fundamental problems associated with stem cell therapy of musc ...

EPFL2019

3D-derivation of uncommitted human muscle stem cells from iPSCs

Matthias Lütolf, Omid Mashinchian, Filippo De Franceschi

MARY ANN LIEBERT, INC2018

Cell-Imprinted Substrates Modulate Differentiation, Redifferentiation, and Transdifferentiation

Philippe Renaud, Arnaud Bertsch, Mojtaba Taghipoor, Omid Mashinchian, Leila Montazeri, Morteza Mahmoudi, Shahin Bonakdar

Differentiation of stem cells into mature cells through the use of physical approaches is of great interest. Here, we prepared smart nanoenvironments by cell-imprinted substrates based on chondrocytes, tenocytes, and semifibroblasts as templates and demons ...

Amer Chemical Soc2016

Osmolarity: A hidden factor in Nanotoxicology

Omid Mashinchian

In the field of drug delivery, long circulating nanocarriers in the blood have many advantages such as targeted drug delivery and sustained release. Based on our current knowledge, evaluation of the effect of long circulating nanocarriers in the blood stre ...

Biomed Central Ltd2016

Possibilities in Germ Cell Research: An Engineering Insight

Omid Mashinchian, Morteza Mahmoudi

Germ cells (GCs) are responsible for fertility and disruptions in their development or function cause infertility. However, current knowledge about the diverse mechanisms involved in GC development and function is still in its infancy. This is mainly becau ...

Elsevier Science London2015