Publications de Sélène-Véronique Glück

cGAS-STING drives ageing-related inflammation and neurodegeneration

Andrea Ablasser, Bastien Mangeat, Muhammet Fatih Gülen, Chong Liu, Vivek Vijay Thacker, Natasha Ella Samson, Sélène-Véronique Glück

Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated impairment and disease(1). Multiple factors can contribute to ageing-associated inflammation(2); however, the molecular pathways that transduce aberrant inflammatory ...

2023

Structural mechanism of cGAS inhibition by the nucleosome

Rudolf Hovius, Beat Fierz, Andrea Ablasser, Baptiste Claude André Guey, Alexiane Clara Decout, Pauline Ambre Melenec, Simone Cavadini, Kristina Makasheva, Sélène-Véronique Glück

The DNA sensor cGAS initiates innate immune responses following microbial infection, cellular stress, and cancer1. Upon activation by double-stranded DNA, cytosolic cGAS produces 2’3’ cyclic GMP-AMP and triggers inflammatory cytokine and type I interferon ...

2020

cGAS regulation and activity during genotoxic stress

Sélène-Véronique Glück

The innate immune system has evolved to detect pathogens through germlineencoded pattern recognition receptors (PRRs). Nucleic acid sensors, a defined class of PRRs, bind to microbial and viral nucleic acids and trigger the production of type I interferons ...

EPFL2020

Innate immunosensing of DNA in cellular senescence

Andrea Ablasser, Sélène-Véronique Glück

2018

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Andrea Ablasser, Muhammet Fatih Gülen, Baptiste Claude André Guey, Sélène-Véronique Glück, Niklas Arndt Schmacke

2017