Publications de Tiffany Babette Angélique Bouchery

Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway

Gerardo Turcatti, Marc Chambon, Anthony Marchand, Nicola Harris, Tiffany Babette Angélique Bouchery, Mati André Marie Moyat

Hookworm infections cause a neglected tropical disease (NTD) affecting ~740 million people worldwide, principally those living in disadvantaged communities. Infections can cause high morbidity due to their impact on nutrient uptake and their need to feed o ...

2022

beta-Glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping

Nicola Harris, Beatrice Volpe, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery, Mati André Marie Moyat

Recent advances in the field of host immunity against parasitic nematodes have revealed the importance of macrophages in trapping tissue migratory larvae. Protective immune mechanisms against the rodent hookworm Nippostrongylus brasiliensis (Nb) are mediat ...

WILEY2022

Immune serum-activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae

Nicola Harris, Beatrice Volpe, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery, Kathleen Shah

Helminth infection represents a major health problem causing approximately 5 million disability-adjusted life years worldwide. Concerns that repeated anti-helminthic treatment may lead to drug resistance render it important that vaccines are developed but ...

WILEY2020

Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps

Arne Seitz, Romain Guiet, Nicola Harris, Beatrice Volpe, Tiffany Babette Angélique Bouchery, Kathleen Shah, Mati André Marie Moyat, Manuel Kulagin

Hookworms cause a major neglected tropical disease, occurring after larvae penetrate the host skin. Neutrophils are phagocytes that kill large pathogens by releasing neutrophil extracellular traps (NETs), but whether they target hookworms during skin infec ...

CELL PRESS2020

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

Nicola Harris, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery

Background Eicosanoid lipid mediators play key roles in type 2 immune responses, for example in allergy and asthma. Macrophages represent major producers of eicosanoids and they are key effector cells of type 2 immunity. We aimed to comprehensively track e ...

WILEY2019

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

Nicola Harris, Kathleen Shah, Tiffany Babette Angélique Bouchery, Tania Carvalho

Group 2 innate lymphoid cells (ILC2s) regulate inflammation, tissue repair and metabolic homeostasis1, and are activated by host-derived cytokines and alarmins1. Discrete subsets of immune cells integrate nervous system cues2, 3, 4, but it remains unclear ...

2017

Only Two Can Tango: Mast Cells Displace Epithelial Cells to Dance with ILC2s

Nicola Harris, Tiffany Babette Angélique Bouchery

Mast cells have been implicated in protective immunity to helminth infection, but the precise mechanism remains unclear. In this issue of Immunity, Shimokawa et al., 2017 report that mast cells are a bridge linking dying epithelial cells with effector type ...

Elsevier2017

Dialogue Between Neutrophils And Hookworms Determines Parasite Development

Nicola Harris, Beatrice Volpe, Tiffany Babette Angélique Bouchery

Amer Soc Trop Med & Hygiene2017

Specific repair by discerning macrophages

Nicola Harris, Tiffany Babette Angélique Bouchery

American Association for the Advancement of Science2017

Exploiting Old Pathogens to Create New Therapeutics

Nicola Harris, Tiffany Babette Angélique Bouchery

Intestinal worms are well known for their potent immuno-modulatory capacity. In a recent study, Navarro et al. (2016) identify a secreted hookworm protein that can suppress allergic responses in both mice and humans. This represents an exciting strategy fo ...

Cell Press2016