Publications de Christian O'Reilly

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep

Henry Markram, Sean Lewis Hill, Michael Reimann, Rodrigo de Campos Perin, James Gonzalo King, Ying Shi, Rajnish Ranjan, Mustafa Anil Tuncel, Samuel Claude Kerrien, Polina Litvak

2023

Rodent somatosensory thalamocortical circuitry: Neurons, synapses, and connectivity

Christian O'Reilly, Elisabetta Iavarone, Jane Yi

As our understanding of the thalamocortical system deepens, the questions we face become more complex. Their investigation requires the adoption of novel experimental approaches complemented with increasingly sophisticated computational modeling. In this r ...

2021

A Text Mining Pipeline Using Active and Deep Learning Aimed at Curating Information in Computational Neuroscience

Christian O'Reilly, Elisabetta Iavarone

The curation of neuroscience entities is crucial to ongoing efforts in neuroinformatics and computational neuroscience, such as those being deployed in the context of continuing large-scale brain modelling projects. However, manually sifting through thousa ...

Springer2019

Nicotine increases sleep spindle activity

Christian O'Reilly

Studies have shown that both nicotine and sleep spindles are associated with enhanced memorisation. Further, a few recent studies have shown how cholinergic input through nicotinic and muscarinic receptors can trigger or modulate sleep processes in general ...

WILEY2019

Experimentally-constrained biophysical models of tonic and burst firing modes in thalamocortical neurons

Henry Markram, Sean Lewis Hill, Ying Shi, Werner Alfons Hilda Van Geit, Christian O'Reilly, Christian Andreas Rössert, Elisabetta Iavarone, Bas-Jan Zandt, Jane Yi

Somatosensory thalamocortical (TC) neurons from the ventrobasal (VB) thalamus are central components in the flow of sensory information between the periphery and the cerebral cortex, and participate in the dynamic regulation of thalamocortical states inclu ...

2019

Visbrain: A Multi-Purpose GPU-Accelerated Open-Source Suite for Multimodal Brain Data Visualization

Christian O'Reilly, Raphaël Vallat

We present Visbrain, a Python open-source package that offers a comprehensive visualization suite for neuroimaging and electrophysiological brain data. Visbrain consists of two levels of abstraction: (1) objects which represent highly configurable neuroori ...

2019

A Framework for Collaborative Curation of Neuroscientific Literature

Sean Lewis Hill, Elisabetta Iavarone, Christian O'Reilly

Large models of complex neuronal circuits require specifying numerous parameters, with values that often need to be extracted from the literature, a tedious and error-prone process. To help establishing shareable curated corpora of annotations, we have dev ...

Frontiers Research Foundation2017

Sleep-dependent consolidation of face recognition and its relationship to REM sleep duration, REM density and Stage 2 sleep spindles

Christian O'Reilly

Face recognition is a highly specialized capability that has implicit and explicit memory components. Studies show that learning tasks with facial components are dependent on rapid eye movement and non-rapid eye movement sleep features, including rapid eye ...

Wiley2017

Meet Spinky: An Open-Source Spindle and K-Complex Detection Toolbox Validated on the Open-Access Montreal Archive of Sleep Studies (MASS)

Christian O'Reilly

Sleep spindles and K-complexes are among the most prominent micro-events observed in electroencephalographic (EEG) recordings during sleep. These EEG microstructures are thought to be hallmarks of sleep-related cognitive processes. Although tedious and tim ...

Frontiers Media Sa2017

Is functional brain connectivity atypical in autism? A systematic review of EEG and MEG studies

Christian O'Reilly

Background Although it is well recognized that autism is associated with altered patterns of over-and under-connectivity, specifics are still a matter of debate. Little has been done so far to synthesize available literature using whole-brain electroenceph ...

Public Library of Science2017