Publications de Tatjana Isabelle Kleele

Mitochondrial Structure, Dynamics, and Physiology Light Microscopy to Disentangle the Network

Suliana Manley, Willi Leopold Stepp, Julius Hans Bernd Winter, Juan Cruz Landoni Martin, Tatjana Isabelle Kleele

Mitochondria serve as energetic and signaling hubs of the cell: This function results from the complex interplay between their structure, function, dynamics, interactions, and molecular organization. The ability to observe and quantify these properties oft ...

ANNUAL REVIEWS2024

Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver

Suliana Manley, Tatjana Isabelle Kleele

All rights reserved.Liver mitochondria play a central role in metabolic adaptations to changing nutritional states, yet their dynamic regulation upon anticipated changes in nutrient availability has remained unaddressed. Here, we found that sensory food pe ...

American Association for the Advancement of Science2024

Mitochondrial membrane tension governs fission

Suliana Manley, Lina Carlini, Dora Mahecic, Tatjana Isabelle Kleele

During mitochondrial fission, key molecular and cellular factors assemble on the outer mitochondrial membrane, where they coordinate to generate constriction. Constriction sites can eventually divide or reverse upon disassembly of the machinery. However, a ...

CELL PRESS2021

Distinct fission signatures predict mitochondrial degradation or biogenesis

Suliana Manley, Hélène Danielle Perreten Lambert, Julius Hans Bernd Winter, Dora Mahecic, Timo Henry René Rey, Tatjana Isabelle Kleele

Mitochondrial fission is a highly regulated process that, when disrupted, can alter metabolism, proliferation and apoptosis(1-3). Dysregulation has been linked to neurodegeneration(3,4), cardiovascular disease(3) and cancer(5). Key components of the fissio ...

2021

Neuronal Growth Cone Size-Dependent and -Independent Parameters of Microtubule Polymerization

Tatjana Isabelle Kleele

2018