Publications de Vivek Vijay Thacker

Human alveolar lining fl uid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells

The elderly population is highly susceptible to developing respiratory diseases, including tuberculosis, a devastating disease caused by the airborne pathogen Mycobacterium tuberculosis ( M.tb ) that kills one person every 18 seconds. Once M.tb reaches the ...

Elsevier Science Inc2024

Mechanopathology of biofilm-like Mycobacterium tuberculosis cords

John McKinney, Graham Knott, Neeraj Dhar, Nicolas Jean Philippe Guex, Jessica Sordet, Maxime Jan, Richa Mishra, Mélanie Thérèse Marie Hannebelle, Vivek Vijay Thacker, Kunal Sharma

Mycobacterium tuberculosis (Mtb) cultured axenically without detergent forms biofilm-like cords, a clinical identifier of virulence. In lung-on-chip (LoC) and mouse models, cords in alveolar cells contribute to suppression of innate immune signaling via nu ...

Cell Press2023

cGAS-STING drives ageing-related inflammation and neurodegeneration

Andrea Ablasser, Bastien Mangeat, Muhammet Fatih Gülen, Chong Liu, Vivek Vijay Thacker, Natasha Ella Samson, Sélène-Véronique Glück

Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated impairment and disease(1). Multiple factors can contribute to ageing-associated inflammation(2); however, the molecular pathways that transduce aberrant inflammatory ...

2023

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

Andrea Ablasser, Muhammet Fatih Gülen, Théo Nass, Vivek Vijay Thacker, Martin Schaller, Kunal Sharma

COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications1,2. Type I interferons (IFNs) have an essential role in the pathogenesis of COVID-19 (refs 3–5). Although rapid induction of type I ...

2022

Rapid endotheliitis and vascular damage characterize SARS‐CoV‐2 infection in a human lung‐on‐chip model

Vivek Vijay Thacker

2021

Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model

John McKinney, Graham Knott, Neeraj Dhar, Maria Clapés Cabrer, François Signorino-Gelo, Vivek Vijay Thacker, Kunal Sharma

2021

Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

John McKinney, Graham Knott, Neeraj Dhar, François Signorino-Gelo, Vivek Vijay Thacker, Kunal Sharma, Thomas Marie Simonet

Uropathogenic Escherichia coli (UPEC) proliferate within superficial bladder umbrella cells to form intracellular bacterial communities (IBCs) during early stages of urinary tract infections. However, the dynamic responses of IBCs to host stresses and anti ...

2021

A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

John McKinney, Neeraj Dhar, Vivek Vijay Thacker, Kunal Sharma

We establish a murine lung-on-chip infection model and use time-lapse imaging to reveal the dynamics of host-Mycobacterium tuberculosis interactions at an air-liquid interface with a spatiotemporal resolution unattainable in animal models and to probe the ...

2020

Lipid-coated nanocapillaries for DNA sensing

Lorenz Jan Steinbock, Vivek Vijay Thacker

We report a simple and efficient way to accomplish the chemical modification of glass nanopores by means of lipid self-assembly. Lipid coating improves the success rate of these glass nanopores as biosensors to detect lambda-DNA. ...

Royal Soc Chemistry2013