Publications de Wei Jiao | EPFL Graph Search

Trio preserves motor synapses and prolongs motor ability during aging

Evelyne Ruchti, Brian Donal McCabe, Soumya Banerjee, Greta Limoni, Samuel William Vernon, Wei Jiao

The decline of motor ability is a hallmark feature of aging and is accompanied by degeneration of motor synaptic terminals. Consistent with this, Drosophila motor synapses undergo characteristic age -dependent structural fragmentation co -incident with dim ...

Cell Press2024

Intact Drosophila central nervous system cellular quantitation reveals sexual dimorphism

Kathryn Hess Bellwald, Ying Shi, Evelyne Ruchti, Brian Donal McCabe, Soumya Banerjee, Samuel William Vernon, Wei Jiao, Gard Spreemann

Establishing with precision the quantity and identity of the cell types of the brain is a prerequisite for a detailed compendium of gene and protein expression in the central nervous system (CNS). Currently, however, strict quantitation of cell numbers has ...

eLIFE SCIENCES PUBL LTD2022

Retromer deficiency in Tauopathy models enhances the truncation and toxicity of Tau

Graham Knott, Evelyne Ruchti, Brian Donal McCabe, Greta Limoni, Catherine Maclachlan, Wei Jiao

Alteration of the levels, localization or post-translational processing of the microtubule associated protein Tau is associated with many neurodegenerative disorders. Here we develop adult-onset models for human Tau (hTau) toxicity in Drosophila that enabl ...

Nature Portfolio2022

Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing

Olivier Burri, Evelyne Ruchti, Brian Donal McCabe, Soumya Banerjee, Samuel William Vernon, Wei Jiao

The decline of neuronal synapses is an established feature of ageing accompanied by the diminishment of neuronal function, and in the motor system at least, a reduction of behavioural capacity. Here, we have investigated Drosophila motor neuron synaptic te ...

Nature Research2021

Supplemental Data - Intact Drosophila Whole Brain Cellular Quantitation reveals Sexual Dimorphism

Brian Donal McCabe, Wei Jiao

Supplemental Figures, Datasets and Movies supporting the manuscript - Intact Drosophila Whole Brain Cellular Quantitation reveals Sexual Dimorphism. Wei Jiao, Gard Spreemann, Evelyne Ruchti, Soumya Banerjee, Ying Shi, R. Steven Stowers, Ka ...

Zenodo2021

Synaptic proximity enables NMDAR signalling to promote brain metastasis

Graham Knott, Douglas Hanahan, Mohammad Sadegh Saghafinia, Qiqun Zeng, Brian Donal McCabe, Wei Jiao, Inti Zlobec, Iacovos Michael, Giovanni Ciriello, Peng Zhang

Metastasis-the disseminated growth of tumours in distant organs-underlies cancer mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and is prevalent in the aggressive basal-like subtype, but is also found at varying freq ...

2019