Publications de Laura Alejandra Velazquez Villegas

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Giacomo Vincenzo Giorgio Von Alvensleben, Hao Li, Maroun Bou Sleiman, Karim Laurent Gariani, Laura Alejandra Velazquez Villegas, Ludger Jan Elzuë Goeminne

Bile acids (BAs) are complex and incompletely understood enterohepatic-derived hormones that control whole-body metabolism. Here, we profiled postprandial BAs in the liver, feces, and plasma of 360 chowor high-fat-diet-fed BXD male mice and demonstrated th ...

Cell Press2022

Molecular physiology of bile acid signaling in health, disease, and aging

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Laura Alejandra Velazquez Villegas

Over the last two decades, bile acids (BAs) have become established as important signaling molecules that enable fine-tuned inter-tissue communication from the liver, their site of production, over the intestine, where they are modified by the gut microbio ...

2021

Central anorexigenic actions of bile acids are mediated by TGR5

Kristina Schoonjans, Alessia Perino, Laura Alejandra Velazquez Villegas, Qingyao Huang, Yu Sun, Nadia Bresciani

Bile acids (BAs) are signalling molecules that mediate various cellular responses in both physiological and pathological processes. Several studies report that BAs can be detected in the brain, yet their physiological role in the central nervous system is ...

2021

Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice

Lilia Noriega Lopez, Laura Alejandra Velazquez Villegas

White adipose tissue (WAT) can differentiate into beige adipose tissue by the browning process. Some polyphenols, including isoflavones, particularly genistein, are suggested to increase the expression of browning markers. There is evidence that consumptio ...

ELSEVIER SCIENCE INC2019

Long-Term Genistein Consumption Modifies Gut Microbiota, Improving Glucose Metabolism, Metabolic Endotoxemia, and Cognitive Function in Mice Fed a High-Fat Diet

Laura Alejandra Velazquez Villegas

2018

TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

Kristina Schoonjans, Alessia Perino, Vera Monica Lemos Da Silva, Mitsunori Nomura, Thijs Pols, Laura Alejandra Velazquez Villegas, Marika Olga Zietak

Nature Research2018