Publications de Olivier Noël Marie Naret

Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania

Jacques Fellay, Olivier Noël Marie Naret, Zhi Ming Xu, Dylan Lawless, Sina Rüeger

The risk and prognosis of tuberculosis (TB) are influenced by a complex interplay between human and bacterial genetic factors. While previous genomic studies have largely examined human and bacterial genomes separately, we adopted an integrated approach to ...

Springer Science and Business Media LLC2025

Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation

Jacques Fellay, Andreas Scheck, Olivier Noël Marie Naret, Arne Schneuing, Zhi Ming Xu, Dylan Lawless

Evolutionary changes in the hepatitis B virus (HBV) genome could reflect its adaptation to host -induced selective pressure. Leveraging paired human exome and ultra -deep HBV genome-sequencing data from 567 affected individuals with chronic hepatitis B, we ...

Cell Press2024

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Jacques Fellay, Olivier Noël Marie Naret, Flavia Aurelia Shoko Hodel, Clara Bonnet

Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic low-grade inflammation. There remains an incomple ...

BMC2022

Improving polygenic prediction with genetically inferred ancestry

Jacques Fellay, Olivier Noël Marie Naret, Flavia Aurelia Shoko Hodel, Zhi Ming Xu

Genome-wide association studies (GWASs) have demonstrated that most common diseases have a strong genetic component from many genetic variants each with a small effect size. GWAS summary statistics have allowed the construction of polygenic scores (PGSs) e ...

ELSEVIER2022

Human genomics of the humoral immune response against polyomaviruses

Jacques Fellay, Christian Axel Wandall Thorball, Olivier Noël Marie Naret, Christian Hammer, Flavia Aurelia Shoko Hodel, Zhi Ming Xu, Petar Scepanovic

Human polyomaviruses are widespread in humans and can cause severe disease in immunocompromised individuals. To identify human genetic determinants of the humoral immune response against polyomaviruses, we performed genome-wide association studies and meta ...

OXFORD UNIV PRESS2021

The genetic architecture of complex human traits at the dawn of genomic medicine

Olivier Noël Marie Naret

The focus of the work presented in this thesis is the exploration of the genetic architecture of complex human traits - at the dawn of genomic medicine. The underlying mechanisms explaining the enormously polygenic nature of most human complex traits are ...

EPFL2021

The influence of human genetic variation on Epstein–Barr virus sequence diversity

Jacques Fellay, Olivier Noël Marie Naret, Christian Hammer, Dylan Lawless, Sina Rüeger

Epstein–Barr virus (EBV) is one of the most common viruses latently infecting humans. Little is known about the impact of human genetic variation on the large inter-individual differences observed in response to EBV infection. To search for a potential imp ...

Nature Research2021

Using reference-fixed principal components to improve polygenic risk score prediction

Jacques Fellay, Olivier Noël Marie Naret

SPRINGERNATURE2020

Is Competition for Resource between Genes a Driving Force of the Omnigenic Architecture?

Olivier Noël Marie Naret

KARGER2020

Correcting for Population Stratification Reduces False Positive and False Negative Results in Joint Analyses of Host and Pathogen Genomes

Jacques Fellay, Olivier Noël Marie Naret, Istvan Bartha, Christian Hammer, Nimisha Chaturvedi

2018