Publications de Gard Spreemann

Dynamics of CLIMP-63 S-acylation control ER morphology

Vassily Hatzimanikatis, Françoise Gisou van der Goot Grunberg, Graham Knott, Kathryn Hess Bellwald, Laurence Gouzi Abrami, Béatrice Kunz, Luciano Andres Abriata, Sylvia Ho, Catherine Maclachlan, Patrick Alain Sandoz

A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by mediat ...

Nature Portfolio2023

Intact Drosophila central nervous system cellular quantitation reveals sexual dimorphism

Kathryn Hess Bellwald, Ying Shi, Evelyne Ruchti, Brian Donal McCabe, Soumya Banerjee, Samuel William Vernon, Wei Jiao, Gard Spreemann

Establishing with precision the quantity and identity of the cell types of the brain is a prerequisite for a detailed compendium of gene and protein expression in the central nervous system (CNS). Currently, however, strict quantitation of cell numbers has ...

eLIFE SCIENCES PUBL LTD2022

Topological exploration of artificial neuronal network dynamics

Kathryn Hess Bellwald, Gard Spreemann

One of the paramount challenges in neuroscience is to understand the dynamics of individual neurons and how they give rise to network dynamics when interconnected. Historically, researchers have resorted to graph theory, statistics, and statistical mechani ...

2019

Using persistent homology to reveal hidden covariates in systems governed by the kinetic Ising model

Gard Spreemann

2018