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Li Tang

Publications associées (49)

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A Manganese Phosphate Nanocluster Activates the cGAS‐STING Pathway for Enhanced Cancer Immunotherapy

Li Tang, Yugang Guo, Yuqing Xie, Min Gao, Armand Kurum, Kewen Lei, Yu Zhao, Xiaomeng Hu, Simon Bart M. Van Herck

Targeting the stimulator of interferon genes (STING) pathway with cyclic dinucleotides (CDNs), the natural STING agonists, is a promising immunotherapeutic strategy for cancer. However, the clinical application of natural CDNs as therapeutics is greatly hi ...

2021

Regulatory T cells engineered with TCR signaling-responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter

Li Tang, Na Li

Adoptive cell transfer of ex vivo expanded regulatory T cells (T-r(egs)) has shown immense potential in animal models of auto- and alloimmunity. However, the effective translation of such T-reg therapies to the clinic has been slow. Because T-reg homeostas ...

2020

T cell force-responsive delivery of anticancer drugs using mesoporous silica microparticles

Li Tang, Kewen Lei

T cell-based cancer immunotherapy has achieved great success in the clinic; however, only a small fraction of patients respond to this therapy. Strategies to specifically and safely augment anticancer activity through controlled delivery of T cell supporti ...

2020

Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine

Li Tang, Lixia Wei, Yu Zhao, Xiaomeng Hu

A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. Here, we devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigen ...

2020

Editorial overview: Tissue, cell and pathway engineering: programming biology for smart therapeutics, microbial cell factory and intelligent biomanufacturing

Li Tang

CURRENT BIOLOGY LTD2020

Disturbed mitochondrial dynamics in CD8(+)TILs reinforce T cell exhaustion

Li Tang, Nicola Vannini, George Coukos, Marcela Rincón-Restrepo, Min Gao, Fabien Franco

Ho and colleagues report that mitochondrial dysfunction and impaired mitophagy triggered by the tumor microenvironment lead to subsequent epigenetic changes and cause permanent T cell exhaustion and dysfunction. The metabolic challenges present in tumors a ...

2020

Materials Horizons Emerging Investigator Series: Li Tang, ecole polytechnique federale de Lausanne (EPFL), Switzerland

Li Tang

Our Emerging Investigator Series features exceptional work by early-career researchers working in the field of materials science. ...

ROYAL SOC CHEMISTRY2020

Outstanding Reviewers for Biomaterials Science in 2019

Li Tang, Yang Li, Peng Huang, Zhen Yang

We would like to take this opportunity to highlight the Outstanding Reviewers for Biomaterials Science in 2019, as selected by the editorial team for their significant contribution to the journal. ...

ROYAL SOC CHEMISTRY2020

Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation

Li Tang

2020

Mechanical Immunoengineering of T-cells for Therapeutic Applications

Li Tang, Armand Kurum, Kewen Lei

T cells, a key component in adaptive immunity, are central to many immunotherapeutic modalities aimed at treating various diseases including cancer, infectious diseases, and autoimmune disorders. The past decade has witnessed tremendous progress in immunot ...

2020

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Regulatory T cells engineered with TCR signaling-responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter

Li Tang, Na Li

2020

T cell force-responsive delivery of anticancer drugs using mesoporous silica microparticles

Li Tang, Kewen Lei

2020

Editorial overview: Tissue, cell and pathway engineering: programming biology for smart therapeutics, microbial cell factory and intelligent biomanufacturing

Li Tang

CURRENT BIOLOGY LTD2020

Materials Horizons Emerging Investigator Series: Li Tang, ecole polytechnique federale de Lausanne (EPFL), Switzerland

Li Tang

Our Emerging Investigator Series features exceptional work by early-career researchers working in the field of materials science. ...

ROYAL SOC CHEMISTRY2020